{"id":1053,"date":"2026-03-05T10:23:14","date_gmt":"2026-03-05T10:23:14","guid":{"rendered":"https:\/\/www.merckvaccines.com\/enflonsia\/?page_id=1053"},"modified":"2026-03-23T09:01:05","modified_gmt":"2026-03-23T09:01:05","slug":"burden-of-disease","status":"publish","type":"page","link":"https:\/\/www.merckvaccines.com\/enflonsia\/burden-of-disease\/","title":{"rendered":"Burden of disease"},"content":{"rendered":"\n\n
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RSV disease in infants can progress unpredictably, potentially leading to hospitalization1<\/sup><\/strong><\/mark><\/h1>

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Infants may develop RSV-associated bronchiolitis and\/or pneumonia<\/strong> with the first RSV infection2<\/sup><\/p>\n\n\n\n

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~81% of all RSV-associated health care interactions<\/strong> in infants from a 2011-2019 study were outpatient visits for lower respiratory infections3,a<\/sup><\/p>\n\n\n\n

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RSV has been the leading cause of hospitalization among infants in the US.<\/strong> The highest rates occurred in the first few months of life and peaked at just 1 month of age in 2015-2020 4-6,b<\/sup><\/span><\/p>\n\n\n\n

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74% of infants hospitalized with RSV infection<\/strong> had no history of premature birth or chronic comorbid conditions (based on a study conducted from December 2016 through September 2020)5,c<\/sup><\/p>\n\n\n\n

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a<\/sup>The study estimated the annual incidence of RSV infections in a US cohort of privately insured children <5 years of age (N = 6,767,107) between 2011 – 2019. Results were stratified by age. Medical encounters evaluated included inpatient, ICU, outpatient, and emergency department visits.3<\/sup><\/p>\n\n\n\n

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b<\/sup>Based on two prospective, population-based, surveillance studies of RSV-associated hospitalizations in US children <5 years of age at seven pediatric medical centers, utilizing NVSN data from 2015\u20132016 and 2016\u20132020.4,5<\/sup> <\/p>\n\n\n\n

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c<\/sup>Based on a prospective surveillance study in RSV-positive children <5 years old (n=4,243) with acute respiratory illness conducted from December 2016 through September 2020 at seven pediatric medical centers. Of these, 2,813 were infants <12 months of age.5<\/sup><\/p>\n\n\n\n

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See how ENFLONSIA works<\/h3>

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Frequently asked questions<\/h3>

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References:<\/strong><\/h2><\/div>\n\n\n\n\n
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  1. Clinical overview of RSV. Centers for Disease Control and Prevention. August 18, 2025. Accessed October 27, 2025. https:\/\/www.cdc.gov\/rsv\/hcp\/clinical-overview\/index.html<\/li>\n\n\n\n
  2. Respiratory syncytial virus. In: Kimberlin DW, Banerjee R, Barnett ED, Lynfield R, Sawyer MH, eds. Red Book: 2024-2027 Report of the Committee on Infectious Diseases<\/em>. 33rd ed. American Academy of Pediatrics. 2024;713-721.<\/li>\n\n\n\n
  3. Nduaguba SO, Tran PT, Shih R, et al. Respiratory syncytial virus incidence in young children in the United States: impact of methodologies and patient characteristics. Influenza Other Respir Viruses<\/em>. 2025;19(4):e70094. doi:10.1111\/irv.70094<\/li>\n\n\n\n
  4. Curns AT, Rha B, Lively JY, et al. Respiratory syncytial virus-associated hospitalizations among children <5 years old: 2016 to 2020. Pediatrics<\/em>. 2024;153(3):e2023062574. doi:10.1542\/peds.2023-062574<\/li>\n\n\n\n
  5. Rha B, Curns AT, Lively JY, et al. Respiratory syncytial virus-associated hospitalizations among young children: 2015-2016. Pediatrics<\/em>. 2020;146(1):e20193611. doi:10.1542\/peds.2019-3611<\/li>\n\n\n\n
  6. RSV in infants and young children. Centers for Disease Control and Prevention. August 30, 2024. Accessed February 27, 2025. https:\/\/www.cdc.gov\/rsv\/infants-young-children\/index.html<\/li>\n<\/ol>\n<\/div>\n\n\n\n\n
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    aThe study estimated the annual incidence of RSV infections in a US cohort of privately insured children <5 years of age (N…<\/p>\n","protected":false},"author":4249,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[203],"ga4_page_birn_id":[],"ga4_page_branding":[220],"ga4_page_businessunit":[],"ga4_page_campaign":[],"ga4_page_content_purpose":[235],"ga4_page_customer_journey_stage":[297],"ga4_page_customer_specialty":[345],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[551],"ga4_page_product":[779],"ga4_page_region":[976],"ga4_page_therapeuticarea":[],"class_list":["post-1053","page","type-page","status-publish"],"yoast_head":"\nRSV Burden of Disease<\/title>\n<meta name=\"description\" content=\"Find information about the potential burden of RSV, including facts about RSV 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