{"id":134,"date":"2024-04-16T11:00:29","date_gmt":"2024-04-16T11:00:29","guid":{"rendered":"https:\/\/www.merckvaccines.com\/gardasil9\/?page_id=134"},"modified":"2025-12-15T11:31:53","modified_gmt":"2025-12-15T11:31:53","slug":"efficacy","status":"publish","type":"page","link":"https:\/\/www.merckvaccines.com\/gardasil9\/efficacy\/","title":{"rendered":"Efficacy"},"content":{"rendered":"<link rel='stylesheet' id='vivid360-spacer-css-css' href='https:\/\/www.merckvaccines.com\/gardasil9\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/spacer\/css\/style.min.css?ver=1765535928' media='all' \/>\n\n<div style=\"background-color:transparent;--desktop-spacer:0px;--tablet-spacer:0px;--mobile-spacer:36px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-heading-css-css' href='https:\/\/www.merckvaccines.com\/gardasil9\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/heading\/css\/style.min.css?ver=1765535927' media='all' \/>\n\n<div class=\"vivid360-heading default-hcp-fontsize default-hcp-tablet-fontsize default-hcp-mobile-fontsize\" id=\"a9fd3e32d-0d19-4bfb-90d0-1c7e60a03ac3\"><h1 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h1FontSizeDesktop);--tabletFontSize:var(--h1FontSizeDesktop);--mobileFontSize:var(--h1FontSizeMobile);--desktopLineHeightSize:var(--h1LineHeightDesktop);--tabletLineHeightSize:var(--h1LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>Efficacy against certain HPV-related cancers and diseases in individuals aged <span class=\"no-wrap-text\">16-26<\/span><\/strong><\/h1><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:28px;--tablet-spacer:28px;--mobile-spacer:36px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:8px;--tablet-spacer:8px;--mobile-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p><strong>Efficacy of GARDASIL<sup>\u00ae<\/sup> [Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant] was assessed in 5 AAHS-controlled clinical studies<\/strong>.<\/p>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<div class=\"wp-block-columns mb-0 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\"><link rel='stylesheet' id='vivid360-card-css-css' href='https:\/\/www.merckvaccines.com\/gardasil9\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/card\/css\/style.min.css?ver=1773226567' media='all' \/>\n\n<div id=\"\" class=\"wp-block-vivid360-card a0dcc8d9b-3483-4b92-b273-16eb7afe8d11 vivid360-block-card has-text-align-center hasBoxShadow card-horizontal has-primary-color has-primary-border-color full-page-width mt-0 mb-0 padding-top-bottom10\" style=\"border-width:0px;border-style:;border-radius:0\"><div class=\"card-content\"><div class=\"card-content-wrap\"><h1 class=\"card-header fontWeightBold\"><strong>~98%<\/strong> <\/h1><div class=\"card-desc has-regular-font-size\">\n<p class=\"has-dark-text-color has-text-color\">n=8493<\/p>\n\n\n\n<p class=\"has-dark-text-color has-text-color\">[95% CI, 93.5-99.8]<\/p>\n\n\n\n<p class=\"has-dark-text-color has-text-color\"><strong>Cervical Cancer<\/strong><\/p>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_7c61d765-2e1f-42d6-aa3e-26eb400666ce mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color has-regular-font-size\">HPV 16- or 18-related CIN 2\/3 or AIS<\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_677ed33c-208e-4f88-a42a-0b47a550a0f8 mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color has-regular-font-size\"><\/p><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:6px;--mobile-spacer:0px;--tablet-spacer:6px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n<\/div><\/div><\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<div id=\"\" class=\"wp-block-vivid360-card a139bec3e-1e0c-45bd-8269-e426d16e05e1 vivid360-block-card has-text-align-center hasBoxShadow card-horizontal has-primary-color full-page-width mt-0 mb-0 padding-top-bottom10\" style=\"border-width:0px;border-style:;border-radius:0\"><div class=\"card-content\"><div class=\"card-content-wrap\"><h1 class=\"card-header fontWeightRegular\"><strong>100%<\/strong><\/h1><div class=\"card-desc has-regular-font-size\">\n<p class=\"has-dark-text-color has-text-color\">n=7772<\/p>\n\n\n\n<p class=\"has-dark-text-color has-text-color\">[95% CI, 55.5-100.0]<\/p>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_2a33c91d-3bcd-4a93-a02d-6fe631fc7b0f mb-1\" id=\"\"><p class=\"has-dark-text-color has-text-color has-regular-font-size\"><strong>Vulvar Cancer<\/strong><\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_9f51dc6f-3fd4-41d9-8a5c-bbf25fa66903 mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color has-regular-font-size\">HPV 16- or 18-related VIN 2\/3<\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_9de16e1a-74f9-4871-b982-cedff661fd2e mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color\"><\/p><\/div><\/div>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:6px;--mobile-spacer:0px;--tablet-spacer:6px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n<\/div><\/div><\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"wp-block-columns mb-0 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<div id=\"\" class=\"wp-block-vivid360-card a7c88fb7b-6cad-4fd4-856a-8db54ab594b4 vivid360-block-card has-text-align-center hasBoxShadow card-horizontal has-primary-color has-primary-border-color full-page-width mt-0 mb-0 padding-top-bottom10\" style=\"border-width:0px;border-style:;border-radius:0\"><div class=\"card-content\"><div class=\"card-content-wrap\"><h1 class=\"card-header fontWeightBold\"><strong>100%<\/strong><\/h1><div class=\"card-desc has-regular-font-size\">\n<p class=\"has-dark-text-color has-text-color\">n=7772<\/p>\n\n\n\n<p class=\"has-dark-text-color has-text-color\">[95% CI, 49.5-100.0]<\/p>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_b1a72120-5d5a-4683-b4ff-41b9880216e6 mb-1\" id=\"\"><p class=\"has-dark-text-color has-text-color has-regular-font-size\"><strong>Vaginal <strong>Cancer<\/strong><\/strong><\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_a1a0ef2d-abd4-4286-be02-45378033b05b mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color has-regular-font-size\">HPV 16- or 18-related VaIN 2\/3<\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_e3b0ca85-a0bf-4d19-9b95-e0a71e855bb2 mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color has-regular-font-size\"><\/p><\/div><\/div>\n\n\n\n<p><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:4px;--mobile-spacer:0px;--tablet-spacer:4px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n<\/div><\/div><\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<div id=\"\" class=\"wp-block-vivid360-card a027476e6-6acd-4228-a417-6ae02446b4ee vivid360-block-card has-text-align-center hasBoxShadow card-horizontal has-primary-color full-page-width mt-0 mb-0 padding-top-bottom10\" style=\"border-width:0px;border-style:;border-radius:0\"><div class=\"card-content\"><div class=\"card-content-wrap\"><h1 class=\"card-header fontWeightRegular\"><strong>~75%<\/strong><\/h1><div class=\"card-desc has-regular-font-size\">\n<p class=\"has-dark-text-color has-text-color\">n=194<\/p>\n\n\n\n<p class=\"has-dark-text-color has-text-color\">[95% CI, 8.8-95.4]<\/p>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_20b683a9-4b37-4a49-a8ea-f0095d0fc3ec mb-1\" id=\"\"><p class=\"has-dark-text-color has-text-color has-regular-font-size\"><strong>Anal <strong>Cancer<\/strong> in Males<\/strong><\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_ee331249-447b-4b2c-b94c-fe2fa61f31bf mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color\">HPV 6-, 11-, 16-, or 18-related AIN 2\/3<\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_c2f33196-7e79-4d89-adf7-c4ff0d28f2db mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color\"><\/p><\/div><\/div>\n\n\n\n<p><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:4px;--mobile-spacer:0px;--tablet-spacer:4px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n<\/div><\/div><\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:10px;--tablet-spacer:10px;--mobile-spacer:10px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p>Efficacy and effectiveness of GARDASIL are relevant to GARDASIL 9 since the vaccines are manufactured similarly and contain 4 of the same HPV L1 VLPs.<\/p>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<div class=\"wp-block-vivid360-button-parent btn-block-container content-width button-justify-left\"><link rel='stylesheet' id='vivid360-button-block-css-css' href='https:\/\/www.merckvaccines.com\/gardasil9\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/button\/css\/style.min.css?ver=1765535927' media='all' \/>\n<link rel='stylesheet' id='vivid360-button-parent-block-css-css' href='https:\/\/www.merckvaccines.com\/gardasil9\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/button-parent\/css\/style.min.css?ver=6.8.5' media='all' \/>\n\n<div class=\"vivid360-button-block fullWidth-mobile\"><a class=\"btn primary primary-regular has-icon icon-right has-primary-border-color has-white-background-color has-primary-color\" role=\"button\" style=\"font-size:14px;letter-spacing:0.86px;border-radius:4px;border-style:solid;justify-content:center;text-align:center;width:100%\" href=\"#studyDesignEff1\" title=\"Study design\" target=\"_self\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Study design\" data-design-module=\"element\" data-event-name=\"element_click\">Study design<span role=\"img\" aria-label=\"icon-info-outline\" class=\"icon-info-outline\"><\/span><\/a><\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<p><strong>Efficacy of GARDASIL 9 against certain cancers caused by HPV Types 31, 33, 45, 52, and 58.<\/strong><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:36px;--tablet-spacer:36px;--mobile-spacer:36px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"wp-block-columns mb-0 is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div id=\"\" class=\"wp-block-vivid360-card aeda7ee8c-3b93-43ad-9bdb-aae583094bc2 vivid360-block-card has-text-align-center hasBoxShadow card-horizontal has-primary-color full-page-width mb-0 mt-0\" style=\"border-width:0px;border-style:;border-radius:0\"><div class=\"card-content\"><div class=\"card-content-wrap\"><h1 class=\"card-header fontWeightBold\">~97%<\/h1><div class=\"card-desc has-regular-font-size\">\n<p class=\"has-dark-text-color has-text-color\">n=6016<\/p>\n\n\n\n<p class=\"has-dark-text-color has-text-color\">[95% CI, 80.9-99.8]<\/p>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_e69ab40e-6177-488c-8a57-a5b88eed3dde mb-1\" id=\"\"><p class=\"has-dark-text-color has-text-color\"><strong>CIN 2\/3, AIS, Cervical<\/strong> <strong><strong>Cancer<\/strong>, VIN 2\/3, VaIN 2\/3, Vulvar<\/strong> <strong><strong>Cancer<\/strong>, and Vaginal <strong>Cancer<\/strong><\/strong><\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_904d9966-f6d0-4acb-b520-733d23361705 mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color\">HPV 31-, 33-, 45-, 52-, and 58-related<\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_a0e4d07b-2979-48f6-bb96-e3f36cc8c67e mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color\">(composite endpoint)<\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_1c42633f-63c7-42b0-8548-477851d008d6 mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color\"><\/p><\/div><\/div>\n\n\n\n<p><\/p>\n<\/div><\/div><\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-vivid360-button-parent btn-block-container content-width button-justify-left\">\n<div class=\"vivid360-button-block fullWidth-mobile\"><a class=\"btn primary primary-regular has-icon icon-right has-primary-border-color has-white-background-color has-primary-color\" role=\"button\" style=\"font-size:14px;letter-spacing:0.86px;border-radius:4px;border-style:solid;justify-content:center;text-align:center;width:100%\" href=\"#studyDesignEff1\" title=\"Study design\" target=\"_self\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Study design\" data-design-module=\"element\" data-event-name=\"element_click\">Study design<span role=\"img\" aria-label=\"icon-info-outline\" class=\"icon-info-outline\"><\/span><\/a><\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:12px;--tablet-spacer:12px;--mobile-spacer:32px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-fontsize default-hcp-tablet-fontsize default-hcp-mobile-fontsize\" id=\"a6f7e6961-6dd7-4807-85f5-aa0e353e671b\"><h2 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h2FontSizeDesktop);--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:var(--h2FontSizeMobile);--desktopLineHeightSize:var(--h2LineHeightDesktop);--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"Demo27to45\"><strong>Efficacy against certain HPV-related cancers and diseases in individuals aged 27-45<sup>a<\/sup><\/strong><\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:8px;--mobile-spacer:16px;--tablet-spacer:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-mobile vivid360-spacer-tablet\"><\/div>\n\n\n\n<p><strong>Efficacy of GARDASIL<sup>\u00ae<\/sup> [Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant] in preventing HPV 6-, 11-, 16-, and 18-related endpoints in women in the PPE population:<\/strong><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:8px;--tablet-spacer:8px;--mobile-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<div id=\"\" class=\"wp-block-vivid360-card ad6890230-56e3-4bab-abcf-a1254b130562 vivid360-block-card has-text-align-center hasBoxShadow card-vertical has-primary-color has-primary-border-color full-page-width mt-0 mb-0\" style=\"border-width:0px;border-style:;border-radius:0\"><div class=\"card-content\"><div class=\"card-content-wrap\"><h1 class=\"card-header fontWeightBold\">~88%<\/h1><div class=\"card-desc has-regular-font-size\">\n<p class=\"has-dark-text-color has-text-color\">n=3253<\/p>\n\n\n\n<p class=\"has-dark-text-color has-text-color\">[95% CI: 75.4%, 94.6%]<\/p>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_b17ac25b-7436-4b45-bcd0-f9a5dbc928bc mb-1\" id=\"\"><p class=\"has-dark-text-color has-text-color has-regular-font-size\"><strong>Genital Warts, VIN, VaIN, Vulvar<\/strong> <strong>Cancer, Vaginal Cancer, Cervical<\/strong> <strong>Dysplasia (Any Grade CIN), AIS, and Cervical Cancer<\/strong><\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_f1635696-4a90-4656-b1a7-b94c83ac3977 mb-0, mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color has-regular-font-size\">HPV 6-, 11-, 16-, and 18-related<\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_5b2c9460-eeec-40e5-84ac-c1496944a16d mb-0, mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color\"><\/p><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:8px;--tablet-spacer:8px;--mobile-spacer:0px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n<\/div><\/div><\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<div id=\"\" class=\"wp-block-vivid360-card ab48f73c5-2294-46f1-b15b-bdd90e5f8e08 vivid360-block-card has-text-align-center hasBoxShadow card-basic has-primary-color full-page-width mt-0 mb-0\" style=\"border-width:0px;border-style:;border-radius:0\"><div class=\"card-content\"><div class=\"card-content-wrap\"><h1 class=\"card-header fontWeightRegular\"><strong>95%<\/strong><\/h1><div class=\"card-desc has-regular-font-size\">\n<p class=\"has-dark-text-color has-text-color\">n=3253<\/p>\n\n\n\n<p class=\"has-dark-text-color has-text-color\">[95% CI: 68.7%, 99.9%]<\/p>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_1ca64d87-6c4f-4a1d-a0bd-58759dc9f085 mb-1\" id=\"\"><p class=\"has-dark-text-color has-text-color\"><strong>Genital Warts, Cervical Dysplasia<\/strong><\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_1c9c6789-bf42-470c-ba9b-e38127693d1f mb-0, mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color\">HPV 6-, 11-, 16-, and 18-related<\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_6c7a34a8-44e1-4334-aee5-326e0a29dd21 mb-0, mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color\"><\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_ee8ee86d-8456-4df3-b78d-79774a4ddca8 mb-0, mt-0\" id=\"\"><p class=\"has-dark-text-color has-text-color\"><\/p><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:30px;--tablet-spacer:55px;--mobile-spacer:0px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n<\/div><\/div><\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:8px;--tablet-spacer:8px;--mobile-spacer:2pxpx\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p><sup>a<\/sup>In men aged 27-45, effectiveness is inferred from efficacy data in women aged 27-45, and supported by immunogenicity data.<\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:8px;--tablet-spacer:0px;--mobile-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p><strong>Effectiveness of GARDASIL 9 against HPV Types 6, 11, 16, 18, 31, 33, 45, 52, and 58 in the PPI population<\/strong>.<\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:8px;--tablet-spacer:8px;--mobile-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p>In women 27-45, effectiveness of GARDASIL 9 was supported by immunobridging comparisons to women 16-26, and supported by immunogenicity data.<\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<p>Safety and effectiveness of GARDASIL 9 have not been established in pregnant women.<\/p>\n\n\n\n<p>Efficacy and effectiveness of GARDASIL are relevant to GARDASIL 9 since the vaccines are manufactured similarly and contain 4 of the same HPV L1 VLPs.<\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<div class=\"wp-block-vivid360-button-parent btn-block-container content-width button-justify-left\">\n<div class=\"vivid360-button-block fullWidth-mobile\"><a class=\"btn primary primary-regular has-icon icon-right has-primary-border-color has-white-background-color has-primary-color\" role=\"button\" style=\"font-size:14px;letter-spacing:0.86px;border-radius:4px;border-style:solid;justify-content:center;text-align:center;width:100%\" href=\"#studyDesignEff2\" title=\"Study design\" target=\"_self\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Study design\" data-design-module=\"element\" data-event-name=\"element_click\">Study design<span role=\"img\" aria-label=\"icon-info-outline\" class=\"icon-info-outline\"><\/span><\/a><\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<p class=\"has-small-font-size\">AAHS, amorphous aluminum hydroxyphosphate sulfate; AIN, anal intraepithelial neoplasia; AIS, adenocarcinoma in situ; CIN, cervical intraepithelial neoplasia; PPE, per-protocol efficacy; VaIN, vaginal intraepithelial neoplasia; VIN, vulvar intraepithelial neoplasia; VLP, virus-like particle.<\/p>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8\"><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:28px;--tablet-spacer:28px;--mobile-spacer:28px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-modal-css-css' href='https:\/\/www.merckvaccines.com\/gardasil9\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/modal\/css\/style.min.css?ver=1769466497' media='all' \/>\n\n<div class=\"wp-block-vivid360-modal\"><div><div class=\"vivid360-modal-block-container is-style-passive-modal\"><div class=\"vivid360-modal-trigger-container\"><span id=\"inlineTrigger\" role=\"link\" data-design-module=\"modal\" data-design-category=\"link\" class=\"vivid360-modal-trigger vivid360-modal-trigger-hide\">studyDesignEff1<\/span><\/div><div class=\"vivid360-modal-container null\"><div class=\"vivid360-modal\"><div class=\"vivid360-modal-content-area\"><a class=\"vivid360-modal-close-modal-span\" role=\"button\" aria-label=\"modal popup close\"><i class=\"icon-close\"><\/i><\/a><div class=\"modal-flex-container\"><div class=\"vivid360-modal-label-container  title-left\" style=\"--titleColor:#1a5a64\"><h3>Study design &amp; additional results<\/h3><\/div><div class=\"vivid360-modal-content-container has-regular-font-size\">\n\n<p><strong><span class=\"no-wrap-text\">GARDASIL<sup>\u00ae<\/sup><\/span>&nbsp;[Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant] study design<\/strong><\/p>\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n<p>Efficacy of GARDASIL was assessed in 5 AAHS-controlled, double-blind, randomized clinical studies evaluating 24,596 individuals in the PPE population (20,541 girls and women 16 to 26 years of age and 4055 boys and men 16 to 26 years of age). Subjects received all 3 vaccinations within 1 year of enrollment, had no major deviations from the study protocol, were na\u00efve (PCR negative and seronegative) to the relevant HPV type(s) (Types 6, 11, 16, and 18) prior to dose 1, and remained PCR negative to the relevant HPV type(s) through 1 month post-dose 3 (Month 7).<\/p>\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n<p><strong>Additional GARDASIL<\/strong>&nbsp;<strong>study results<\/strong><\/p>\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n<p>Cervical: 2 HPV 16- or 18-related CIN 2\/3 or AIS cases in the group receiving GARDASIL (n=8493) vs 112 cases in the group receiving placebo (n=8464) [95% CI, 93.5-99.8];<\/p>\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n<p>Vulvar\/Vaginal: No HPV 16- or 18-related VIN 2\/3 or VaIN 2\/3 cases in either group receiving GARDASIL (n=7772) vs 10 cases in the VIN 2\/3 group receiving placebo (n=7744) [95% CI, 55.5-100.0], and 9 cases in the VaIN 2\/3 group receiving placebo (n=7744) [95% CI, 49.5-100.0];<\/p>\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n<p>Anal: 3 (HPV Types 6-, 11-, 16-, or 18-related) AIN 2\/3 cases in the male group receiving GARDASIL (n=194) vs 13 cases in the male group receiving placebo (n=208) [95% CI, 8.8-95.4];<\/p>\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n<p>Genital Warts: 3 HPV 6-, 11-, 16-, or 18-related genital warts cases in the male group receiving GARDASIL<sup>\u00ae<\/sup>&nbsp;[Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant] (n=1394) vs 28 genital warts cases in the male group receiving placebo (n=1404) [95% CI, 65.3-97.9]; External Genital Lesions (males): 3 cases HPV Types 6-, 11-, 16-, or 18-related external genital lesions in the group receiving GARDASIL (n=1394) vs 32 cases of external genital lesions in the group receiving placebo (n=1404) [95% CI, 70.1-98.2]; External Genital Lesions (females): 2 HPV 6-, 11-, 16-, or 18-related genital warts cases in the group receiving GARDASIL (n=7900) vs 193 cases in the group receiving placebo (n=7902) [95% CI, 96.2-99.9].<\/p>\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n<p><strong>GARDASIL<sup>\u00ae<\/sup>9&nbsp; [Human Papillomavirus 9-valent Vaccine, Recombinant] study design<\/strong><\/p>\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n<p>Efficacy of GARDASIL 9 in 16\u2010 through 26\u2010year\u2010old girls and women was assessed in an active comparator-controlled, double\u2010blind, randomized clinical study that included a total of 14, 204 women (GARDASIL 9=7099; GARDASIL<sup>\u00ae<\/sup>&nbsp;[Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant]=7105) who were enrolled and vaccinated without prescreening for the presence of HPV infection. Subjects were followed up with a median duration of 40 months (range 0 to 64 months) after the last vaccination and efficacy of all endpoints was measured starting after the Month 7 visit. Efficacy was evaluated in subjects who received all 3 vaccinations within 1 year of enrollment, had no major deviations from the study protocol, were na\u00efve to the relevant HPV type(s) (Types 31, 33, 45, 52, and 58) prior to dose 1, and remained PCR negative to the relevant HPV type(s) through 1 month post\u2010dose 3 (Month 7).<\/p>\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n<p><strong>GARDASIL 9&nbsp;study results<\/strong><\/p>\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n<p>One HPV 31-, 33-, 45-, 52-, and 58-related case (CIN 2\/3, AIS, cervical cancer, VIN 2\/3, VaIN 2\/3, vulvar cancer, and vaginal cancer) in the group receiving GARDASIL 9 (n=6016) vs 30 cases in the group receiving GARDASIL (n=6017) [95% CI, 80.9\u201099.8].<\/p>\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_8cace54c-5d3c-450d-823f-a5b41e3d3825 mb-0\" id=\"\"><p class=\"has-small-font-size\">AAHS, amorphous aluminum hydroxyphosphate sulfate; AIN, anal intraepithelial neoplasia; AIS, adenocarcinoma in situ; CI, confidence interval; CIN, cervical intraepithelial neoplasia; PCR, polymerase chain reaction; PPE, per-protocol efficacy; VaIN, vaginal intraepithelial neoplasia; VIN, vulvar intraepithelial neoplasia.<\/p><\/div><\/div>\n\n<\/div><div class=\"vivid360-modal-button-container desktop-container\"><div class=\"vivid360-button-block\"><a class=\"btn primary primary-regular btn-confirm  vivid360-modal-dismiss-button\" role=\"button\" aria-label=\"Button 1\" style=\"font-size:14px\" href=\"#!\" title=\"Button 1\" target=\"_self\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Button 1\" data-design-module=\"element\">Button 1<\/a><\/div><div class=\"vivid360-button-block\"><a class=\"btn primary primary-regular btn-dismissive  vivid360-modal-dismiss-button\" role=\"button\" aria-label=\"Button 2\" style=\"font-size:14px\" href=\"#!\" title=\"Button 2\" target=\"_self\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Button 2\" data-design-module=\"element\">Button 2<\/a><\/div><\/div><\/div><\/div><div class=\"vivid360-modal-button-container mobile-container \"><div class=\"vivid360-button-block\"><a class=\"btn primary primary-regular btn-confirm  vivid360-modal-dismiss-button\" role=\"button\" aria-label=\"Button 1\" style=\"font-size:14px\" href=\"#!\" title=\"Button 1\" target=\"_self\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Button 1\" data-design-module=\"element\">Button 1<\/a><\/div><div class=\"vivid360-button-block\"><a class=\"btn primary primary-regular btn-dismissive  vivid360-modal-dismiss-button\" role=\"button\" aria-label=\"Button 2\" style=\"font-size:14px\" href=\"#!\" title=\"Button 2\" target=\"_self\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Button 2\" data-design-module=\"element\">Button 2<\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-vivid360-modal\"><div><div class=\"vivid360-modal-block-container is-style-passive-modal\"><div class=\"vivid360-modal-trigger-container\"><span id=\"inlineTrigger\" role=\"link\" data-design-module=\"modal\" data-design-category=\"link\" class=\"vivid360-modal-trigger vivid360-modal-trigger-hide\">studyDesignEff2<\/span><\/div><div class=\"vivid360-modal-container null\"><div class=\"vivid360-modal\"><div class=\"vivid360-modal-content-area\"><a class=\"vivid360-modal-close-modal-span\" role=\"button\" aria-label=\"modal popup close\"><i class=\"icon-close\"><\/i><\/a><div class=\"modal-flex-container\"><div class=\"vivid360-modal-label-container  title-left\" style=\"--titleColor:#1a5a64\"><h3>Study design &amp; additional results<\/h3><\/div><div class=\"vivid360-modal-content-container has-regular-font-size\">\n\n<p><strong>GARDASIL<sup>\u00ae<\/sup>&nbsp;[Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant] study design<\/strong><\/p>\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n<p>A clinical trial evaluated efficacy of GARDASIL in 3253 women 27 through 45 years of age, based on a combined endpoint of HPV 6-, 11-, 16-, or 18-related persistent infection, genital warts, vulvar and vaginal dysplastic lesions of any grade, CIN of any grade, AIS, and cervical cancer. These women were randomized 1:1 to receive either GARDASIL or AAHS control. The PPE population received all 3 vaccinations within 1 year of enrollment, did not have major deviations from the study protocol, were na\u00efve (PCR negative and seronegative) to the relevant HPV type(s) (Types 6, 11, 16, and 18) prior to dose 1 and remained PCR negative to the relevant HPV type(s) through 1 month post-dose 3 (Month 7). The clinical trial was conducted in 2 phases: a base study and a long-term study extension.<\/p>\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n<p><strong>Additional&nbsp;study results<\/strong><\/p>\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_3cb08fb4-21f8-4838-b6d5-324199ded1dd mb-0\" id=\"\"><p>In the base study (median duration of follow-up of 3.5 years post-dose 3), the efficacy of GARDASIL against the combined incidence of HPV 6-, 11-, 16-, and 18-related persistent&nbsp; infection, genital warts, VIN, VaIN, vulvar cancer, vaginal cancer, cervical dysplasia (any grade CIN), AIS, and cervical cancer in the PPE population was 87.7% (95% CI, 75.4%, 94.6%). The efficacy estimate for the combined endpoint was driven primarily by prevention of persistent infection. The efficacy of GARDASIL against the combined incidence of HPV 6-, 11-, 16-, and 18-related genital warts or cervical dysplasia was 95.0% (95% CI, 68.7%, 99.9%) in the PPE population. While no statistically significant efficacy was demonstrated for GARDASIL in the base study for prevention of cervical intraepithelial neoplasia grades 2 and 3 (CIN 2\/3), adenocarcinoma in situ (AIS), or cervical cancer related to HPV Types 16 and 18, there was 1 case of CIN 2\/3 observed in the GARDASIL group and 5 cases in the placebo group. The CIN 2 case in the GARDASIL group tested positive by PCR for HPV 16 and HPV 51.<\/p><\/div><\/div>\n\n<\/div><div class=\"vivid360-modal-button-container desktop-container\"><div class=\"vivid360-button-block\"><a class=\"btn primary primary-regular btn-confirm  vivid360-modal-dismiss-button\" role=\"button\" aria-label=\"Button 1\" style=\"font-size:14px\" href=\"#!\" title=\"Button 1\" target=\"_self\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Button 1\" data-design-module=\"element\">Button 1<\/a><\/div><div class=\"vivid360-button-block\"><a class=\"btn primary primary-regular btn-dismissive  vivid360-modal-dismiss-button\" role=\"button\" aria-label=\"Button 2\" style=\"font-size:14px\" href=\"#!\" title=\"Button 2\" target=\"_self\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Button 2\" data-design-module=\"element\">Button 2<\/a><\/div><\/div><\/div><\/div><div class=\"vivid360-modal-button-container mobile-container \"><div class=\"vivid360-button-block\"><a class=\"btn primary primary-regular btn-confirm  vivid360-modal-dismiss-button\" role=\"button\" aria-label=\"Button 1\" style=\"font-size:14px\" href=\"#!\" title=\"Button 1\" target=\"_self\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Button 1\" data-design-module=\"element\">Button 1<\/a><\/div><div class=\"vivid360-button-block\"><a class=\"btn primary primary-regular btn-dismissive  vivid360-modal-dismiss-button\" role=\"button\" aria-label=\"Button 2\" style=\"font-size:14px\" href=\"#!\" title=\"Button 2\" target=\"_self\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Button 2\" data-design-module=\"element\">Button 2<\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-vivid360-modal\"><div><div class=\"vivid360-modal-block-container is-style-passive-modal-two-btn\"><div class=\"vivid360-modal-trigger-container\"><span id=\"inlineTrigger\" role=\"link\" data-design-module=\"modal\" data-design-category=\"link\" class=\"vivid360-modal-trigger vivid360-modal-trigger-hide\">ExternalSitePopup<\/span><\/div><div class=\"vivid360-modal-container null\"><div class=\"vivid360-modal\"><div class=\"vivid360-modal-content-area\"><a class=\"vivid360-modal-close-modal-span\" role=\"button\" aria-label=\"modal popup close\"><i class=\"icon-close\"><\/i><\/a><div class=\"modal-flex-container\"><div class=\"vivid360-modal-label-container  title-left\" style=\"--titleColor:#00857c\"><h2>By clicking on this link, you will be leaving Merck Vaccines.<\/h2><\/div><div class=\"vivid360-modal-content-container has-regular-font-size\"><\/div><div class=\"vivid360-modal-button-container desktop-container\"><div class=\"vivid360-button-block\"><a class=\"btn secondary secondary-regular btn-confirm has-color-alternate-primary-border-color has-color-alternate-primary-color vivid360-modal-dismiss-button\" role=\"button\" aria-label=\"Cancel\" style=\"font-size:14px;border-style:solid\" href=\"#!\" title=\"Cancel\" target=\"_self\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Cancel\" data-design-module=\"element\">Cancel<\/a><\/div><div class=\"vivid360-button-block\"><a class=\"btn primary primary-regular btn-dismissive has-color-alternate-primary-border-color has-color-alternate-primary-background-color vivid360-modal-action-button\" role=\"button\" aria-label=\"Proceed\" style=\"font-size:14px;border-style:solid\" href=\"https:\/\/gardasil9.com\/\" title=\"Proceed\" target=\"_blank\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Proceed\" data-design-module=\"element\">Proceed<\/a><\/div><\/div><\/div><\/div><div class=\"vivid360-modal-button-container mobile-container \"><div class=\"vivid360-button-block\"><a class=\"btn secondary secondary-regular btn-confirm has-color-alternate-primary-border-color has-color-alternate-primary-color vivid360-modal-dismiss-button\" role=\"button\" aria-label=\"Cancel\" style=\"font-size:14px;border-style:solid\" href=\"#!\" title=\"Cancel\" target=\"_self\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Cancel\" data-design-module=\"element\">Cancel<\/a><\/div><div class=\"vivid360-button-block\"><a class=\"btn primary primary-regular btn-dismissive has-color-alternate-primary-border-color has-color-alternate-primary-background-color vivid360-modal-action-button\" role=\"button\" aria-label=\"Proceed\" style=\"font-size:14px;border-style:solid\" href=\"https:\/\/gardasil9.com\/\" title=\"Proceed\" target=\"_blank\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Proceed\" data-design-module=\"element\">Proceed<\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Efficacy of GARDASIL\u00ae [Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant] was assessed in 5 AAHS-controlled clinical studies. Efficacy&#8230;<\/p>\n","protected":false},"author":708,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[214],"ga4_page_birn_id":[],"ga4_page_branding":[231],"ga4_page_businessunit":[239],"ga4_page_campaign":[],"ga4_page_content_purpose":[259],"ga4_page_customer_journey_stage":[307],"ga4_page_customer_specialty":[353],"ga4_page_experience":[],"ga4_page_indication":[436],"ga4_page_material_intent":[512],"ga4_page_product":[548],"ga4_page_region":[739],"ga4_page_therapeuticarea":[784],"class_list":["post-134","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Efficacy of GARDASIL\u00ae9 (Human Papillomavirus 9-valent Vaccine, Recombinant)<\/title>\n<meta name=\"description\" content=\"View 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