{"id":96,"date":"2024-07-22T18:48:15","date_gmt":"2024-07-22T18:48:15","guid":{"rendered":"https:\/\/www.merckvaccines.com\/proquad\/?page_id=96"},"modified":"2026-01-08T07:01:23","modified_gmt":"2026-01-08T07:01:23","slug":"reconstitution","status":"publish","type":"page","link":"https:\/\/www.merckvaccines.com\/proquad\/reconstitution\/","title":{"rendered":"Reconstitution"},"content":{"rendered":"<link rel='stylesheet' id='vivid360-spacer-css-css' href='https:\/\/www.merckvaccines.com\/proquad\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/spacer\/css\/style.min.css?ver=1765194012' media='all' \/>\n\n<div style=\"background-color:transparent;--desktop-spacer:0px;--tablet-spacer:16px;--mobile-spacer:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-hero-css-css' href='https:\/\/www.merckvaccines.com\/proquad\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/hero\/css\/style.min.css?ver=1765194012' media='all' \/>\n\n<div id=\"\" class=\"wp-block-vivid360-hero\"><div class=\"vivid360-hero-container align-left align-middle ratio-70-30 horizontal desktop text-align-left has-primary-dark-color is-overlay-style is-card-overlay is-opaque-overlay mobile-is-default-style mobile-uses-custom-styles\" style=\"border-width:0;border-style:solid;border-top-left-radius:0;border-top-right-radius:0;border-bottom-right-radius:0;border-bottom-left-radius:0;--minHeight:218px;--mobileMinHeight:162px\"><div class=\"wide_screens hidden\" data-value=\"default\"><\/div><picture><source media=\"(max-width: 767px)\" srcset=\"https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2025\/12\/6.0_Professional_Resource_ProQuad_Banner_1128px_v2.svg?w=767\"\/><source media=\"(min-width: 768px) and (max-width:1024px)\" srcset=\"https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2025\/12\/6.0_Professional_Resource_ProQuad_Banner_1128px_v2.svg?w=1024\"\/><source media=\"(min-width: 1025px) and (max-width:1440px)\" srcset=\"https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2025\/12\/6.0_Professional_Resource_ProQuad_Banner_1128px_v2.svg?w=1440\"\/><img decoding=\"async\" width=\"1128\" height=\"242.58\" loading=\"lazy\" data-src=\"https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2025\/12\/6.0_Professional_Resource_ProQuad_Banner_1128px_v2.svg?w=1488\" src=\"https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2025\/12\/6.0_Professional_Resource_ProQuad_Banner_1128px_v2.svg?w=1488\" alt=\"\" class=\"hero-image\" style=\"--desktop-focal-x:92%;--desktop-focal-y:54%;--mobile-focal-x:15%;--mobile-focal-y:50%;--tablet-focal-x:92%;--tablet-focal-y:54%\"\/><div class=\"capoverlay-container-desktop right-bottom show custom_margin hide_mobile isMobileOverlayChecked label\" style=\"--top-margin:;--bottom-margin:;--left-margin:;--right-margin:8px\"><div class=\"overlay-caption-schema\">Actor Portrayal<\/div><\/div><\/picture><div class=\"hero-wrapper\"><div class=\"hero-content\"><h1 style=\"--headlineFontSize:30px;--headlineFontSizeTablet:36px;--headlineFontSizeMobile:22px;--headlineLineHeight:45px;--headlineLineHeightTablet:45px;--headlineLineHeightMobile:33px\" class=\"hero-title fontWeightRegular\"><strong>Reconstitute ProQuad<sup>\u00ae<\/sup> (Measles, Mumps, Rubella and Varicella Virus Vaccine Live) using a prefilled diluent syringe<\/strong><\/h1><p class=\"hero-description\"><\/p><div class=\"hero-btn-group\"><\/div><div class=\"hero-caption\"><\/div><\/div><\/div><\/div><div class=\"hero-caption-2desktop\"><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:30px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:20%\"><\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\"><link rel='stylesheet' id='vivid360-video-module-css-css' href='https:\/\/www.merckvaccines.com\/proquad\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/video-module\/css\/style.min.css?ver=1765966675' media='all' \/>\n\n<div id=\"\" class=\"wp-block-vivid360-video-module vivid360-block-video-module video-module-center full-page-width\"><div class=\"video-wrapper\"><div data-tracking-video=\"6366805696112\" class=\"vivid360-block-video-module-video-content\"><div><video id=\"video-block\" data-design-category=\"Video\" data-account=\"1905768940001\" data-player=\"default\" data-embed=\"default\" controls data-video-id=\"6366805696112\" data-playlist-id=\"\" data-application-id=\"\" class=\"vjs-fluid video-js\" data-jobcode=\"US-QDX-00633\" aria-labelledby=\"video_label\" aria-describedby=\"video_description\"><\/video><\/div><\/div><div id=\"video_label\" hidden>BrightCove Video<\/div><div id=\"video_description\" aria-live=\"polite\" role=\"caption\" hidden><\/div><figure class=\"text-align-left\"><figcaption><\/figcaption><\/figure><\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:20%\"><\/div>\n<\/div>\n\n\n\n<p>Hold the syringe barrel in one hand and <strong>unscrew the syringe tip<\/strong> <strong>cap<\/strong> by twisting it <strong>counterclockwise<\/strong>. <strong>Attach a needle<\/strong> by <strong>twisting clockwise<\/strong> until the needle fits securely on the syringe.<\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:14px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-image-css-css' href='https:\/\/www.merckvaccines.com\/proquad\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/image\/css\/style.min.css?ver=1777274844' media='all' \/>\n\n<div class=\"wp-block-vivid360-image\"><div class=\"img-container \"><figure class=\"wp-block-vivid360-image is-style-default has-mobile-image aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_1_Figure_FINAL_HI.png?w=1024\" alt=\"\" class=\"wp-image-302  style-noshadow   \" width=\"256\" height=\"154\" style=\"height:154px;width:256px\" srcset=\"https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_1_Figure_FINAL_HI.png 1045w, https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_1_Figure_FINAL_HI.png?resize=300,181 300w, https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_1_Figure_FINAL_HI.png?resize=768,463 768w, https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_1_Figure_FINAL_HI.png?resize=1024,617 1024w\" sizes=\"auto, (max-width: 256px) 100vw, 256px\" \/><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_1_Figure_FINAL_HI.png?w=1024\" alt=\"\" class=\"wp-image-302  style-noshadow mobile-image mobHeightAuto mobWidthAuto \" width=\"256\" height=\"154\" title=\"\" style=\"height:617px;width:1023px\" srcset=\"https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_1_Figure_FINAL_HI.png 1045w, https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_1_Figure_FINAL_HI.png?resize=300,181 300w, https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_1_Figure_FINAL_HI.png?resize=768,463 768w, https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_1_Figure_FINAL_HI.png?resize=1024,617 1024w\" sizes=\"auto, (max-width: 256px) 100vw, 256px\" \/><\/figure><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p>Visually inspect the vaccine for discoloration. <strong>Slowly inject the entire volume<\/strong> of sterile diluent prefilled syringe into the lyophilized vaccine vial.<strong> Gently agitate to dissolve completely.<\/strong> Discard if the lyophilized vaccine cannot be dissolved. Do not use the product if particulates are present or if it appears discolored. <\/p>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<p>Before reconstitution, the lyophilized vaccine is a white to pale yellow compact crystalline plug. ProQuad, when reconstituted, is a clear pale yellow to light pink liquid.<\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"wp-block-vivid360-image\"><div class=\"img-container \"><figure class=\"wp-block-vivid360-image is-style-default aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_2_Figure_FINAL_HI.png\" alt=\"\" class=\"wp-image-303  style-noshadow   \" width=\"193\" height=\"234\" style=\"height:234px;width:193px\" srcset=\"https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_2_Figure_FINAL_HI.png 770w, https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_2_Figure_FINAL_HI.png?resize=247,300 247w, https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_2_Figure_FINAL_HI.png?resize=768,935 768w\" sizes=\"auto, (max-width: 193px) 100vw, 193px\" \/><\/figure><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<p>Visually inspect the vaccine again for discoloration. <strong>Withdraw and administer the entire volume of the reconstituted vaccine.<\/strong><\/p>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"wp-block-vivid360-image\"><div class=\"img-container \"><figure class=\"wp-block-vivid360-image is-style-default aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_3_Figure_FINAL_HI.png?w=579\" alt=\"\" class=\"wp-image-304  style-noshadow   \" width=\"158\" height=\"280\" style=\"height:280px;width:158px\" srcset=\"https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_3_Figure_FINAL_HI.png 631w, https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_3_Figure_FINAL_HI.png?resize=170,300 170w, https:\/\/www.merckvaccines.com\/proquad\/wp-content\/uploads\/sites\/174\/2024\/07\/CAT_PFS-Diluent_Step_3_Figure_FINAL_HI.png?resize=579,1024 579w\" sizes=\"auto, (max-width: 158px) 100vw, 158px\" \/><\/figure><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:24px;--tablet-spacer:24px;--mobile-spacer:24px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n<link rel='stylesheet' id='vivid360-list-parent-css-css' href='https:\/\/www.merckvaccines.com\/proquad\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/list-parent\/css\/style.css?ver=1765194012' media='all' \/>\n\n<div class=\"vivid-block-list2 content-width  \">\n<ul style=\"--listBulletColor:#333\" class=\"list-bullet-color\">\n<li>If not used immediately, the reconstituted vaccine may be stored at room temperature, protected from light, for up to 30 minutes. Discard reconstituted vaccine if it is not used within 30 minutes.<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:28px;--tablet-spacer:20px;--mobile-spacer:20px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"wp-block-vivid360-button-parent btn-block-container content-width button-justify-center\"><link rel='stylesheet' id='vivid360-button-block-css-css' href='https:\/\/www.merckvaccines.com\/proquad\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/button\/css\/style.min.css?ver=1765966675' media='all' \/>\n<link rel='stylesheet' id='vivid360-button-parent-block-css-css' href='https:\/\/www.merckvaccines.com\/proquad\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/button-parent\/css\/style.min.css?ver=6.8.5' media='all' \/>\n\n<div class=\"vivid360-button-block fullWidth-mobile\"><a class=\"btn primary primary-regular\" role=\"button\" style=\"font-size:14px;letter-spacing:0.86px;border-radius:4px;border-style:solid;justify-content:center;text-align:center;width:100%\" href=\"https:\/\/www.merckvaccines.com\/varivax\/wp-content\/uploads\/sites\/81\/2025\/10\/US-MMR-00601_MMRV-Family-Storage-Reconstitution-Leave-Behind_v7_CORAL-1.pdf\" title=\"Get reconstitution PDF\" target=\"_blank\" rel=\"noopener\" data-design-category=\"button\" data-design-label=\"Get reconstitution PDF\" data-design-module=\"element\" data-event-name=\"element_click\">Get reconstitution PDF<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:28px;--tablet-spacer:20px;--mobile-spacer:20px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Hold the syringe barrel in one hand and unscrew the syringe tip cap by twisting it counterclockwise. Attach a needle by twisting&#8230;<\/p>\n","protected":false},"author":522,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[228],"ga4_page_businessunit":[239],"ga4_page_campaign":[],"ga4_page_content_purpose":[255],"ga4_page_customer_journey_stage":[320],"ga4_page_customer_specialty":[375],"ga4_page_experience":[],"ga4_page_indication":[484],"ga4_page_material_intent":[582],"ga4_page_product":[762],"ga4_page_region":[934],"ga4_page_therapeuticarea":[951],"class_list":["post-96","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Reconstitution of ProQuad\u00ae (Measles, Mumps, Rubella and Varicella Virus Vaccine Live)<\/title>\n<meta name=\"description\" content=\"Watch a video that shows how to reconstitute ProQuad\u00ae (Measles, Mumps, Rubella and Varicella Virus Vaccine Live) and download a Reconstitution Instructions PDF.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.merckvaccines.com\/proquad\/reconstitution\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Reconstitution of ProQuad\u00ae (Measles, Mumps, Rubella and Varicella Virus Vaccine Live)\" \/>\n<meta property=\"og:description\" content=\"Watch a video that shows how to reconstitute ProQuad\u00ae (Measles, Mumps, Rubella and Varicella Virus Vaccine Live) and download a Reconstitution Instructions PDF.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.merckvaccines.com\/proquad\/reconstitution\/\" \/>\n<meta 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