{"id":426,"date":"2023-05-16T17:04:50","date_gmt":"2023-05-16T17:04:50","guid":{"rendered":"https:\/\/www.merckvaccines.com\/recombivax-hb\/?page_id=426"},"modified":"2026-05-07T12:38:06","modified_gmt":"2026-05-07T12:38:06","slug":"dosage-administration","status":"publish","type":"page","link":"https:\/\/www.merckvaccines.com\/recombivax-hb\/dosage-administration\/","title":{"rendered":"Dosage and administration"},"content":{"rendered":"<link rel='stylesheet' id='vivid360-heading-css-css' href='https:\/\/www.merckvaccines.com\/recombivax-hb\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/heading\/css\/style.min.css?ver=1765194012' media='all' \/>\n\n<div class=\"vivid360-heading\" id=\"ab1d585ff-02f2-4e36-8bf6-c87bbd413f6e\"><h1 class=\"has-primary-dark-color content-width fontWeightRegular\" style=\"--desktopFontSize:36px;--tabletFontSize:36px;--mobileFontSize:24px;--desktopLineHeightSize:45px;--tabletLineHeightSize:45px;--mobileLineHeightSize:\" id=\"\"><strong>Dosage and administration for <span class=\"no-wrap-text\">RECOMBIVAX HB<sup>\u00ae<\/sup><\/span> [Hepatitis B Vaccine (Recombinant)]<\/strong><\/h1><\/div>\n\n\n<link rel='stylesheet' id='vivid360-spacer-css-css' href='https:\/\/www.merckvaccines.com\/recombivax-hb\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/spacer\/css\/style.min.css?ver=1765194012' media='all' \/>\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<div style=\"background-color:transparent;height:8px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-8 spacer-undefined\"><\/div>\n\n\n\n<div class=\"vivid360-heading default-hcp-tablet-fontsize\" id=\"a0854c634-5168-4859-9d38-862748abde93\"><h2 class=\"has-primary-dark-color content-width fontWeightRegular\" style=\"--desktopFontSize:24px;--tabletFontSize:var(--h2FontSizeDesktop);--mobileFontSize:20px;--desktopLineHeightSize:36px;--tabletLineHeightSize:var(--h2LineHeightDesktop);--mobileLineHeightSize:\" id=\"\"><strong>Dosing schedule for <span class=\"no-wrap-text\">RECOMBIVAX HB<\/span><\/strong><\/h2><\/div>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"ab285b0e9-fc85-48b1-9a60-18010c84a807\"><h4 class=\"has-white-color has-text-align-center has-primary-dark-background-color content-width fontWeightRegular\" style=\"--desktopFontSize:var(--h4FontSizeDesktop);--tabletFontSize:var(--h4FontSizeDesktop);--mobileFontSize:var(--h4FontSizeMobile);--desktopLineHeightSize:var(--h4LineHeightDesktop);--tabletLineHeightSize:var(--h4LineHeightDesktop);--mobileLineHeightSize:;--tabletAlign:center;--mobileAlign:center\" id=\"\"><strong>Dosage and administration<\/strong> <strong>for <span class=\"no-wrap-text\">RECOMBIVAX HB<\/span><\/strong><\/h4><\/div>\n\n\n<link rel='stylesheet' id='vivid360-table-css-css' href='https:\/\/www.merckvaccines.com\/recombivax-hb\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/table\/css\/style.min.css?ver=6.8.5' media='all' \/>\n<link rel='stylesheet' id='vivid360-table-sortable-css-css' href='https:\/\/www.merckvaccines.com\/recombivax-hb\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/table\/css\/sortable.min.css?ver=6.8.5' media='all' \/>\n\n<figure class=\"wp-block-vivid360-table content-width\"><table id=\"a323f0094-1ced-45e3-9f17-b603be2dbd73-vivid360-table-id\" class=\"a323f0094-1ced-45e3-9f17-b603be2dbd73 squished\" style=\"--tableBorder:1px solid #000;--tableBorderRadius:0\"><thead><tr style=\"background-color:#f5f2f0\"><th class=\"has-text-align-center has-white-background-color has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\" width=\"\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">Group<\/mark><\/strong><\/th><th class=\"has-text-align-center has-white-background-color has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">Dose<\/mark><\/strong><\/th><th class=\"has-text-align-center has-white-background-color has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\" width=\"\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">Schedule<\/mark><\/strong><\/th><\/tr><\/thead><tbody><tr style=\"background-color:#f5f2f0\"><td class=\"has-text-align-center has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\" width=\"\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\"><strong>Infants<sup>a<\/sup>, Children, and Adolescents <\/strong><\/mark><br><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">0\u201319 years of age (Pediatric\/adolescent formulation)<\/mark><\/td><td class=\"has-text-align-center has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">5 mcg&nbsp;(0.5 mL)<\/mark><\/td><td class=\"has-text-align-center has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\" width=\"\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">3 doses at 0, 1, and 6 months<\/mark><\/td><\/tr><tr style=\"background-color:#f5f2f0\"><td class=\"has-text-align-center has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\" width=\"\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\"><strong>Adolescents<sup>b<\/sup><\/strong> <\/mark><br><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">11 through 15 years of age (Adult formulation)&nbsp;<\/mark><\/td><td class=\"has-text-align-center has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">10 mcg<sup>c<\/sup>&nbsp;(1.0 mL)<\/mark><\/td><td class=\"has-text-align-center has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\" width=\"\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">2 doses at 0 and 4\u20136 months<\/mark><\/td><\/tr><tr style=\"background-color:#f5f2f0\"><td class=\"has-text-align-center has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\" width=\"\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\"><strong>Adults <\/strong><\/mark><br><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">\u2265 20 years of age (Adult formulation)<\/mark><\/td><td class=\"has-text-align-center has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">10 mcg<sup>c<\/sup>&nbsp;(1.0 mL)<\/mark><\/td><td class=\"has-text-align-center has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\" width=\"\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">3 doses at 0, 1, and 6 months<\/mark><\/td><\/tr><tr style=\"background-color:#f5f2f0\"><td class=\"has-text-align-center has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\" width=\"\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\"><strong>Predialysis and Dialysis Patients<sup>d<\/sup> <\/strong><\/mark><br><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">(Dialysis formulation)<\/mark><\/td><td class=\"has-text-align-center has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">40 mcg&nbsp;(1.0 mL)<\/mark><\/td><td class=\"has-text-align-center has-small-font-size\" style=\"color:undefined!important\" data-align=\"center\" width=\"\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#333e48\" class=\"has-inline-color\">3 doses at 0, 1, and 6 months<\/mark><\/td><\/tr><\/tbody><\/table><div class=\"\"><small class=\"table-caption\"><\/small><\/div><\/figure>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_6f3a0206-8c78-4396-93a9-292d5f98b018 \" id=\"\"><p class=\"has-text-color has-small-font-size\" style=\"color:#333e48\"><strong><sup>a<\/sup>For specific recommendations for infants, see American Academy of Pediatrics (AAP) recommendations.<sup>1<\/sup><\/strong><\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_5a281e67-5aec-407c-b4aa-b7703b8e54fa \" id=\"\"><p class=\"has-text-color has-small-font-size\" style=\"color:#333e48\"><sup>b<\/sup>Adolescents (11 through 15 years of age) may receive either regimen: 3 x 5 mcg (pediatric formulation) or 2 x 10 mcg (adult formulation).<\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_ecca28cf-8ce2-4ba6-9804-fb8b6f729aef \" id=\"\"><p class=\"has-text-color has-small-font-size\" style=\"color:#333e48\"><sup>c<\/sup>If the suggested dose (10 mcg) is not available, the appropriate dosage can be achieved with two 5 mcg doses. However, the dialysis formulation may be used only for adult predialysis\/dialysis patients.<\/p><\/div><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_a6df220d-126e-44f0-8b26-32545de34cdc \" id=\"\"><p class=\"has-text-color has-small-font-size\" style=\"color:#333e48\"><sup>d<\/sup>See also recommendations for revaccination of predialysis and dialysis patients in [Dosage and administration (2.4)] of the Prescribing Information.<\/p><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;height:16px\" class=\"wp-block-vivid360-spacer vivid360-spacer spacer-16\"><\/div>\n\n\n\n<div class=\"paragraph-wrapper\"><div class=\"_59fc9f84-465a-4480-94be-431f4cb82d1c \" id=\"\"><p class=\"has-text-color has-small-font-size\" style=\"color:#333e48\">RECOMBIVAX HB should not be administered in the gluteal region, as injections given in the buttocks have resulted in lower seroconversion rates than expected.<\/p><\/div><\/div>\n\n\n\n<div style=\"background-color:transparent;--desktop-spacer:4px;--tablet-spacer:4px;--mobile-spacer:4px\" class=\"wp-block-vivid360-spacer vivid360-spacer-desktop vivid360-spacer-tablet vivid360-spacer-mobile\"><\/div>\n\n\n\n<div class=\"vivid360-heading\" id=\"ae8404f52-d189-4d75-bec5-903e2c96b44a\"><h2 class=\"content-width fontWeightRegular\" style=\"--desktopFontSize:18px;--tabletFontSize:18px;--mobileFontSize:16px;--desktopLineHeightSize:27px;--tabletLineHeightSize:27px;--mobileLineHeightSize:\" id=\"\"><strong>Reference<\/strong><\/h2><\/div>\n\n\n<link rel='stylesheet' id='vivid360-list-parent-css-css' href='https:\/\/www.merckvaccines.com\/recombivax-hb\/wp-content\/themes\/cex-wpvip-mhh-merck-vivid360-theme-1-12\/blocks\/list-parent\/css\/style.css?ver=1765194012' media='all' \/>\n\n<div class=\"vivid-block-list2 content-width  \">\n<ol style=\"--listBulletColor:#333\" class=\"list-bullet-color\">\n<li>Recommended Child and Adolescent Immunization Schedule for Ages 18 Years or Younger. American Academy of Pediatrics. Accessed January 15, 2026. https:\/\/downloads.aap.org\/AAP\/PDF\/AAP-Immunization-Schedule.pdf<\/li>\n<\/ol>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>aFor specific recommendations for infants, see American Academy of Pediatrics (AAP) recommendations.1 bAdolescents (11 through 15 years of age) may receive either&#8230;<\/p>\n","protected":false},"author":701,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[227],"ga4_page_businessunit":[235],"ga4_page_campaign":[],"ga4_page_content_purpose":[248],"ga4_page_customer_journey_stage":[299],"ga4_page_customer_specialty":[370],"ga4_page_experience":[],"ga4_page_indication":[466],"ga4_page_material_intent":[570],"ga4_page_product":[633],"ga4_page_region":[942],"ga4_page_therapeuticarea":[961],"class_list":["post-426","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dosage and Administration for RECOMBIVAX HB\u00ae [Hepatitis B Vaccine (Recombinant)]<\/title>\n<meta name=\"description\" content=\"View 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