{"id":108,"date":"2024-06-26T13:53:59","date_gmt":"2024-06-26T13:53:59","guid":{"rendered":"https:\/\/www.merckvaccines.com\/vaxneuvance\/?page_id=108"},"modified":"2025-12-22T11:02:54","modified_gmt":"2025-12-22T11:02:54","slug":"serotypes","status":"publish","type":"page","link":"https:\/\/www.merckvaccines.com\/vaxneuvance\/serotypes\/","title":{"rendered":"Serotypes"},"content":{"rendered":"\n\n
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Consider IPD protection against what matters1<\/sup><\/strong><\/strong><\/h1>

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When it comes to protecting your pediatric patients against IPD, the number of serotypes in a vaccine is just one aspect to consider1,2<\/sup><\/strong><\/strong><\/h2><\/div>\n\n\n\n
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Although more than 100 S. pneumoniae<\/em> serotypes have been documented, only a few of them cause most pediatric pneumococcal infections2<\/sup><\/strong><\/mark><\/h3><\/div>\n<\/div>\n<\/div>\n\n\n\n
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In a pooled analysis from 2019-2023, ~1 in 4 cases of IPD<\/span><\/mark> <\/strong>in children younger than 5 years old were caused by serotypes1,a<\/sup><\/p><\/div><\/div><\/p>\n<\/div>\n<\/div>\n\n\n\n

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\"Serotype\"Serotype<\/figure><\/div><\/div>\n<\/div>\n\n\n\n
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These 3 key serotypes are associated with higher morbidity and mortality rates in children.3-5,a<\/sup><\/span><\/mark><\/strong><\/p><\/div><\/div><\/p>\n\n\n\n

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Percentage of IPD caused by Serotype 3 in children <5 years of age (1998\u20132023)6,7<\/sup><\/p>\n\n\n\n\n

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Serotype 3 continues to be a leading cause of pediatric IPD<\/mark> <\/strong>despite being included in PCVs for over 15 years1,8<\/sup><\/p><\/div><\/div><\/p>\n<\/div>\n<\/div>\n\n\n\n

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a<\/sup>In a pooled analysis of national-level CDC ABC surveillance data from 2019\u20132023, the top 5 IPD-causing serotypes in children under 5 years of age were 19F, 3, 22F, 15C, and 33F. Serotype 15C is not included in any recommended pediatric PCV in the US.1,9,10<\/sup><\/p>\n\n\n\n

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ABC, Active Bacterial Core; CDC, Centers for Disease Control and Prevention; IPD, invasive pneumococcal disease; PCV, pneumococcal conjugate vaccine.<\/p>\n\n\n\n

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Get details on early disease protection<\/h3>

Get details on early disease protection<\/a><\/p><\/div>

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See immunogenicity data<\/h3>

See immunogenicity data<\/a><\/p><\/div>

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Learn about special populations<\/strong><\/h3>

Learn about special populations<\/a><\/p><\/div>

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View safety & tolerability data<\/strong><\/h3>

View safety & tolerability data<\/a><\/p><\/div>

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References:<\/strong><\/h2><\/div>\n\n\n\n\n
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  1. Centers for Disease Control and Prevention (CDC). 2019\u20132023 serotype data for invasive pneumococcal disease cases by age group from Active Bacterial Core surveillance. Updated March 14, 2025. Accessed August 26, 2025. data.cdc.gov\/d\/qvzb-qs6p\/visualization<\/li>\n\n\n\n
  2. Gierke R, Wodi P, Kobayashi M. Epidemiology and Prevention of Vaccine-Preventable Diseases<\/em> (Pink Book). 14th edition. Chapter 17: Pneumococcal disease. Centers for Disease Control and Prevention. Last reviewed August 2021. Accessed May 16, 2025. https:\/\/www.cdc.gov\/pinkbook\/hcp\/table-of-contents\/chapter-17-pneumococcal-disease.html<\/span><\/li>\n\n\n\n
  3. Hu T, Weiss T, Owusu-Edusei K, Petigara T. Health and economic burden associated with 15-valent pneumococcal conjugate vaccine serotypes in children in the United States. J Med Econ. <\/em>2020;23(12):1653-1660. doi:10.1080\/13696998.2020.1840216<\/li>\n\n\n\n
  4. Yildirim M, Keskinocak P, Hinderstein S, et al. A comprehensive analysis of serotype-specific invasive capacity, clinical presentations, and mortality trends of invasive pneumococcal disease. Vaccine. <\/em>2025;47:126692. doi:10.1016\/j.vaccine.2024.126692<\/li>\n\n\n\n
  5. Varghese J, Chochua S, Tran T, et al. Multistate population and whole genome sequence-based strain surveillance of invasive pneumococci recovered in the USA during 2017. Clin Microbiol Infect.<\/em> 2020;26(4):512.e1-512. e10. doi:10.1016\/j.cmi.2019.09.008<\/li>\n\n\n\n
  6. Centers for Disease Control and Prevention (CDC). 1998\u20132023 Serotype 3 data for invasive pneumococcal disease cases by age group from Active Bacterial Core surveillance. Updated March 14, 2025. Accessed March 21, 2025. data.cdc.gov\/d\/qvzb-qs6p\/visualization<\/li>\n\n\n\n
  7. Centers for Disease Control and Prevention (CDC). 1998\u20132023 serotype data for invasive pneumococcal disease cases by age group from Active Bacterial Core surveillance. Updated March 14, 2025. Accessed March 21, 2025. data.cdc.gov\/d\/qvzb-qs6p\/visualization<\/li>\n\n\n\n
  8. Prevnar 13. Prescribing Information. Pfizer, Inc.; 2019.<\/li>\n\n\n\n
  9. Pneumococcal vaccine recommendations. Centers for Disease Control and Prevention. Last reviewed October 26, 2024. Accessed November 18, 2024. https:\/\/www.cdc.gov\/pneumococcal\/hcp\/vaccine-recommendations\/index.html<\/span><\/li>\n\n\n\n
  10. Prevnar 20. Prescribing Information. Pfizer, Inc.; 2023<\/li>\n<\/ol>\n<\/div>\n\n\n\n\n
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    Percentage of IPD caused by Serotype 3 in children <5 years of age (1998\u20132023)6,7 Serotype 3 continues to be a leading cause…<\/p>\n","protected":false},"author":708,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_trash_the_other_posts":false,"editor_notices":[],"footnotes":""},"ga4_page_audience":[1166],"ga4_page_birn_id":[],"ga4_page_branding":[227],"ga4_page_businessunit":[235],"ga4_page_campaign":[],"ga4_page_content_purpose":[243],"ga4_page_customer_journey_stage":[295],"ga4_page_customer_specialty":[359],"ga4_page_experience":[],"ga4_page_indication":[1215],"ga4_page_material_intent":[575],"ga4_page_product":[777],"ga4_page_region":[1025],"ga4_page_therapeuticarea":[1120],"class_list":["post-108","page","type-page","status-publish"],"yoast_head":"\nSerotype Coverage With VAXNEUVANCE\u00ae (Pneumococcal 15-valent Conjugate Vaccine)<\/title>\n<meta name=\"description\" content=\"HCPs 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