{"id":2801,"date":"2025-12-09T12:42:41","date_gmt":"2025-12-09T12:42:41","guid":{"rendered":"https:\/\/www.merckvaccines.com\/vaxneuvance\/?page_id=2801"},"modified":"2025-12-22T11:04:03","modified_gmt":"2025-12-22T11:04:03","slug":"early-disease-protection","status":"publish","type":"page","link":"https:\/\/www.merckvaccines.com\/vaxneuvance\/early-disease-protection\/","title":{"rendered":"Early Disease Protection"},"content":{"rendered":"\n\n
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Consider IPD protection when it matters<\/strong><\/h1>

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Early protection matters in the first year of life when the risk of pediatric IPD is the highest<\/strong>1-3<\/strong><\/sup>
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The incidence<\/strong><\/mark> of IPD in children was ~2x as high<\/mark><\/strong> in the first year of life than that of children 1-4 years of age combined.1,a<\/sup><\/p>\n\n<\/div><\/div><\/div><\/div>\n<\/div>\n\n\n\n

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The death rate<\/mark><\/strong> due to IPD was at least 2x as high<\/strong><\/mark> in infants than in any other pediatric age group.1,b<\/sup><\/p>\n\n\n

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a<\/sup>Based on pooled analysis of national-level CDC ABC surveillance data from 2019\u20132023, representing ~35 million people surveyed annually in 10 states across the US. Regional variations may exist. IPD incidence rates were 10.3 in <1 year, 8.0 in 1 year, 4.6 in 2\u20134 years, 5.5 in 1\u20134 years, and 1.4 in 5\u201317 years.1<\/sup><\/p>\n\n\n\n

b<\/sup>Based on pooled analysis of national-level CDC ABC surveillance data from 2019\u20132023, representing ~35 million people in 10 states across the US. Regional variations may exist. Rates of death per 100,000 population for ABCs areas were 0.62 in <1 year, 0.15 in 1 year, 0.28 in 2\u20134 years, and 0.06 in 5\u201317 years. For each age group during 2019\u20132023, deaths within the ABCs areas and national estimates, respectively, were in <1 year: ABCs areas: 12 deaths in 1,945,628 persons, national estimate: ~113 deaths in 18,392,796 persons; in 1 year: ABCs areas: 3 deaths in 1,965,119 persons, national estimate: ~28 deaths in 18,625,903 persons; in 2\u20134 years: ABCs areas: 17 deaths in 6,054,551 persons, national estimate: ~163 deaths in 58,047,830 persons; in 5\u201317 years: ABCs areas: 18 deaths in 28,391,356 persons, national estimate: ~173 deaths in 272,550,379.1<\/sup><\/p>\n<\/div>\n\n\n\n

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PCVs are CDC recommended as a 4-dose series2<\/sup><\/strong><\/p>\n\n\n\n

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c<\/sup>Dose 1 may be given as early as 6 weeks of age. <\/p>\n\n\n\n

d<\/sup>The recommended interval between doses is 4 to 8 weeks. <\/p>\n\n\n\n

e<\/sup>The 4th dose should be administered at approximately 12 through 15 months of age and at least 2 months after the 3rd dose.<\/p>\n\n\n\n

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Despite the CDC’s recommendation, not all babies complete the 4-dose series.2,4,5,f<\/sup><\/strong><\/strong><\/p>\n\n\n\n

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f<\/sup>NIS-Child, a random digit-dialed telephone survey of parents\/guardians of children aged 19\u201335 months that the CDC used to estimate the vaccination coverage with ACIP-recommended vaccines in the US among children born in 2020 and 2021.4<\/sup><\/p>\n\n\n\n

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ABC, Active Bacterial Core; ACIP, Advisory Committee on Immunization Practices; CDC, Centers for Disease Control and Prevention; IPD, invasive pneumococcal disease; PCV, pneumococcal conjugate vaccine; NIS-Child, National Immunization Survey – Child; VFC, Vaccines for Children.<\/p>\n\n\n\n

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Stay updated on serotypes<\/strong><\/h3>

Stay updated on serotypes<\/a><\/p><\/div>

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See immunogenicity data<\/strong><\/h3>

See immunogenicity data<\/a><\/p><\/div>

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Learn about special populations<\/strong><\/h3>

Learn about special populations<\/a><\/p><\/div>

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View safety & tolerability data<\/strong><\/h3>

View safety & tolerability data<\/a><\/p><\/div>

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References:<\/strong><\/h2><\/div>\n\n\n\n\n
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  1. Active Bacterial Core surveillance (ABCs). Surveillance reports. Centers for Disease Control and Prevention. Updated August 21, 2025. Last accessed August 28, 2025. https:\/\/www.cdc.gov\/abcs\/reports\/index.html<\/li>\n\n\n\n
  2. Centers for Disease Control and Prevention. Recommended child and adolescent immunization schedule for ages 18 years or younger, United States, 2025. Revised October 7, 2025. Accessed October 12, 2025. https:\/\/www.cdc.gov\/vaccines\/hcp\/imz-schedules\/downloads\/child\/0-18yrs-child-combined-schedule.pdf<\/li>\n\n\n\n
  3. Gierke R, Wodi P, Kobayashi M. Epidemiology and Prevention of Vaccine-Preventable Diseases<\/em> (Pink Book). 14th edition. Chapter 17: Pneumococcal disease. Centers for Disease Control and Prevention. Last reviewed August 2021. Accessed May 16, 2025. https:\/\/www.cdc.gov\/pinkbook\/hcp\/table-of-contents\/chapter-17-pneumococcal-disease.html<\/li>\n\n\n\n
  4. Hill HA, et al. Decline in Vaccination Coverage by Age 24 Months and Vaccination Inequities Among Children Born in 2020 and 2021 \u2014 National Immunization Survey-Child, United States, 2021\u20132023. MMWR Morb Mortal Wkly Rep<\/em>, pages 844\u2013853.<\/li>\n\n\n\n
  5. Centers for Disease Control and Prevention (CDC). Supplementary Table 1. Estimated vaccination coverage by age 24 months* among children born during 2020-2021,\u2020 by selected vaccines and doses and health insurance status\u00a7 \u2013 National Immunization Survey- Child, United States, 2021-2023. MMWR<\/em>. 2024;73(38). Accessed January 22, 2025. https:\/\/stacks.cdc.gov\/view\/cdc\/162213<\/li>\n<\/ol>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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