Common billing codes for ENFLONSIATM (clesrovimab-cfor)

Below is a list of codes that may be relevant for ENFLONSIA and its administration. The information provided here is compiled from sources believed to be accurate, but Merck makes no representation that it is accurate. Consult the relevant manual and/or other guidelines for a description of each code to determine the appropriateness of a particular code and for information on additional codes. This information is subject to change. Merck cautions that payer coding requirements vary and can frequently change, so it’s important to regularly check with each payer as to payer-specific requirements.

You are solely responsible for determining the appropriate codes and for any action you take in billing. The information provided here is not intended to be definitive or exhaustive, and is not intended to replace the guidance of a qualified professional advisor. Merck makes no warranties or guarantees, expressed or implied, concerning the accuracy or appropriateness of this information for your particular use given the frequent changes in public and private payer billing. The use of this information does not guarantee payment or that any payment received will cover your costs. Diagnosis codes should be selected only by a health care professional.

Billing codes for ENFLONSIA

These commonly-used codes may apply to private payer reimbursement claims.

CPT codes for ENFLONSIADescription
CPT Code for ENFLONSIA
90382Respiratory syncytial virus, monoclonal antibody, seasonal dose, 0.7 mL, for intramuscular use1
Administration CPT Codes
96380Administration of respiratory syncytial virus, monoclonal antibody, seasonal dose by intramuscular injection, with counseling by physician or other qualified health professional2
96381Administration of respiratory syncytial virus, monoclonal antibody, seasonal dose by intramuscular injection.2

CPT, Current Procedural Terminology. CPT is a registered trademark of the American Medical Association.

ICD-10-CM code3Description
Z29.11Encounter for prophylactic immunotherapy for respiratory syncytial virus (RSV)3

ICD-10-CM, International Classification of Diseases, Tenth Revision, Clinical Modification.

National drug codes (NDC) and CVX code

Supplied packagesNDC unit of sale
1 single-dose 105 mg/0.7 mL pre-filled syringe10-Digit: 0006-5073-01
 
11-Digit: 00006-5073-01
10 single-dose 105 mg/0.7 mL pre-filled syringes10-Digit: 0006-5073-02
 
11-Digit 00006-5073-02
CVX Code1332

Please note: The NDC above is the billable NDC that appears on the carton.

CVX, Clinical Vaccines Administered; NDC, National Drug Code

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References:

  1. Immunization Information Systems (IIS): CPT codes mapped to CVX codes. Centers for Disease Control and Prevention. Last reviewed November 26, 2025. January 6, 2025. https://www2a.cdc.gov/vaccines/iis/iisstandards/vaccines.asp?rpt=cpt
  2. American Medical Association. CPT® 2025 Professional Edition. 1st ed. American Medical Association; 2024:868–870.
  3. ICD-10-CM tabular list of diseases and injuries. Centers for Medicare & Medicaid Services. Last updated February 26, 2025. Accessed April 8, 2025. https://www.cms.gov/medicare/coding-billing/icd-10-codes
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Indications and Usage

ENFLONSIA is indicated for the prevention of respiratory syncytial virus (RSV) lower respiratory tract disease in neonates and infants who are born during or entering their first RSV season.

Selected Safety Information

  • Do not administer ENFLONSIA to infants with a history of serious hypersensitivity reactions, including anaphylaxis, to any component of ENFLONSIA.
  • Serious hypersensitivity reactions, including anaphylaxis, have been observed with other human immunoglobulin G1 (IgG1) monoclonal antibodies. If signs or symptoms of a clinically significant hypersensitivity reaction or anaphylaxis occur, initiate appropriate medications and/or supportive therapy.
  • ENFLONSIA may interfere with some immunologically-based RSV diagnostic assays (i.e., rapid antigen tests) as observed in laboratory studies. Confirmation using a reverse transcriptase polymerase chain reaction (RT-PCR) assay is recommended when rapid antigen assay results are negative and clinical observations are consistent with RSV infection.
  • The most common adverse reactions were injection-site erythema (3.8%), injection-site swelling (2.7%), and rash (2.3%).

 

Dosage and Administration

  • The recommended dose is 105 mg administered as a single intramuscular (IM) injection.
  • For neonates and infants born during the RSV season, administer ENFLONSIA once starting from birth. For infants born outside the RSV season, administer ENFLONSIA once prior to the start of their first RSV season considering 5 months duration of protection by ENFLONSIA.
  • For infants undergoing cardiac surgery with cardiopulmonary bypass during or entering their first RSV season, an additional 105 mg dose is recommended as soon as the infant is stable after surgery to ensure adequate clesrovimab-cfor serum levels.

 

Before administering ENFLONSIA, please read the accompanying Prescribing Information. The Patient Information also is available.

Indications and Usage
Selected Safety Information

ENFLONSIA is indicated for the prevention of respiratory syncytial virus (RSV) lower respiratory tract disease in neonates and infants who are born during or entering their first RSV season.

Selected Safety Information

  • Do not administer ENFLONSIA to infants with a history of serious hypersensitivity reactions, including anaphylaxis, to any component of ENFLONSIA.
  • Serious hypersensitivity reactions, including anaphylaxis, have been observed with other human immunoglobulin G1 (IgG1) monoclonal antibodies. If signs or symptoms of a clinically significant hypersensitivity reaction or anaphylaxis occur, initiate appropriate medications and/or supportive therapy.
  • ENFLONSIA may interfere with some immunologically-based RSV diagnostic assays (i.e., rapid antigen tests) as observed in laboratory studies. Confirmation using a reverse transcriptase polymerase chain reaction (RT-PCR) assay is recommended when rapid antigen assay results are negative and clinical observations are consistent with RSV infection.
  • The most common adverse reactions were injection-site erythema (3.8%), injection-site swelling (2.7%), and rash (2.3%).

 

Dosage and Administration

  • The recommended dose is 105 mg administered as a single intramuscular (IM) injection.
  • For neonates and infants born during the RSV season, administer ENFLONSIA once starting from birth. For infants born outside the RSV season, administer ENFLONSIA once prior to the start of their first RSV season considering 5 months duration of protection by ENFLONSIA.
  • For infants undergoing cardiac surgery with cardiopulmonary bypass during or entering their first RSV season, an additional 105 mg dose is recommended as soon as the infant is stable after surgery to ensure adequate clesrovimab-cfor serum levels.

 

Before administering ENFLONSIA, please read the accompanying Prescribing Information. The Patient Information also is available.