Human Papillomavirus (HPV)-Related Diseases

  • How widespread is HPV?
    • In the United States,

      ~19,000 new HPV infections

      occur in teens and young adults every day.1,a

    • Every year, there are ~14 million new HPV infections nationwide.1

      About 50% of them are in 15- to 24-year-olds.1

    a15- to 24-year-olds.

    For most people, HPV clears on its own. But, for others who don't clear the virus, it could cause certain cancers and other diseases.1

  • How is HPV acquired and transmitted?

    HPV is most commonly acquired and transmitted through sexual intercourse. However, it can be spread through many types of genital contact—intercourse is not necessary. Individuals can acquire HPV from others who are infected but who don't have visible disease or lesions.1

  • What are the potential outcomes of HPV?

    For most people, HPV clears on its own. But, for others who don’t clear the virus, it could cause certain cancers and diseases.1

    HPV-related cancer casesTotal percent contribution of HPVb
    Cervical cancer2 90%2
    Vulvar cancer2 65%2
    Vaginal cancer2 75%2
    Anal cancer2 90%2

    bPercentages include all HPV types.

    HPV-related cancers can take years, even decades to develop.3

    Not all cervical, vulvar, vaginal, and anal cancer cases are caused by HPV.2

  • What are the incidence rates of HPV-related cancer?

    For most people, HPV clears on its own. But, for others who don’t clear the virus, it could cause certain cancers and diseases.1

    It is estimated that in the United States, there are

    10,900 new cases of cervical cancer every year that are caused by HPV.2,c

    cEstimate represents cervical cancer cases caused by all oncogenic HPV types.

    While not all vaginal and vulvar cancers are caused by HPV, in the United States each year, about 3,400 women are diagnosed with vaginal or vulvar cancer caused by HPV.2,d

    dEstimate represents vulvar and vaginal cancer cases caused by all oncogenic HPV types.

    While not all anal cancers are caused by HPV, each year nationwide, there are about 6,200 new anal cancer cases that are caused by HPV.2,e

    eEstimate represents anal cancer cases caused by all oncogenic HPV types.

    HPV-related cancers can take years, even decades to develop.3

Disease Information

Additional disease information can be found at:

CDC Information

CDC=Centers for Disease Control and Prevention.

US-GSL-01136 11/19
1. Centers for Disease Control and Prevention (CDC). Human papillomavirus. In: Hamborsky J, Kroger A, Wolfe C, eds. Epidemiology and Prevention of Vaccine-Preventable Diseases. 13th ed. Washington DC: Public Health Foundation; 2015:175-186.
2. Senkomago V, Henley J, Thomas CC, et al. Human papillomavirus—attributable cancers — United States, 2012–2016. MMWR Morb Mortal Wkly Rep. 2019;68(33):724-728.
3. Centers for Disease Control and Prevention (CDC). 6 types of cancer caused by HPV. https://www.cdc.gov/hpv/parents/cancer.html. Updated April 29, 2019. Accessed May 7, 2019.
4. Walboomers JMM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189(1):12–19.
5. de Sanjose S, Alemany L, Ordi J, et al. Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva. Eur J Cancer. 2013;49(16):3450–3461.
6. Alemany L, Saunier M, Tinoco L, et al. Large contribution of human papillomavirus in vaginal neoplastic lesions: a worldwide study in 597 samples. Eur J Cancer. 2014;50(16):2846–2854.
7. Alemany L, Saunier M, Alvarado-Cabrero I, et al. Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide. Int J Cancer. 2015;136(1):98–107.
8. Guan P, Howell-Jones R, Li N, et al. Human papillomavirus types in 115,789 HPV-positive women: a meta-analysis from cervical infection to cancer. Int J Cancer. 2012;131(10):2349–2359.
9. Garland SM, Steben M, Sings HL, et al. Natural history of genital warts: analysis of the placebo arm of 2 randomised phase III trials of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine. J Infect Dis. 2009;199(6):805–814.
10. American Cancer Society (ACS). Cancer Facts & Figures 2015. Atlanta, GA: American Cancer Society; 2015.
11. Chesson HW, Ekwueme DU, Saraiya M, et al. Estimates of the annual direct medical costs of the prevention and treatment of disease associated with human papillomavirus in the United States. Vaccine. 2012;30(42):6016–6019.