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Learn More About the MMRV Vaccine Family
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Find information about the MMRV Family

For decades, Merck combination vaccines have helped in the fight against childhood diseases.


The MMRV Family of vaccines from Merck includes M-M-R®II (Measles, Mumps, and Rubella Virus Vaccine Live), VARIVAX® (Varicella Virus Vaccine Live), and ProQuad® (Measles, Mumps, Rubella, and Varicella Virus Vaccine Live).

It is the only complete family of vaccines that has helped to protect children for decades from measles, mumps, rubella, and varicella.

1ST DOSE

At First Dose the ACIP Recommends Administering M-M-R ® II (Measles, Mumps, and Rubella Vaccine Live) and VARIVAX® (Varicella Virus Vaccine Live) as Separate Injections

12-15 MONTHS

ACIP recommendation

The ACIP recommends a measles, mumps, and rubella (MMR) vaccine and varicella vaccine be administered as separate injections, unless a parent/caregiver expresses a preference for a combination MMRV vaccine at 1st dose at ages 12-47 months.1

2ND DOSE

The ACIP Recommends the Combination MMRV Vaccine ProQuad® (Measles, Mumps, Rubella and Varicella Vaccine Live) Over Separate Injections for the Second Dose

4-6 YEARS

ACIP recommendation

The ACIP generally prefers a combination MMRV vaccine over separate injections of its equivalent component vaccines (ie, MMR vaccine and varicella vaccine).1


ACIP, Advisory Committee on Immunization Practices.

One way to follow the ACIP preference for 1st dose is M-M-R®II and VARIVAX (routinely given at 12-15 months of age)1,a

  • The ACIP recommends the measles, mumps, and rubella (MMR) vaccine and varicella vaccine be administered as separate injections, unless a parent/caregiver expresses a preference for the combination MMRV vaccine at 1st dose at ages 12-47 months.1
  • If you are considering a combination MMRV vaccine for the 1st dose, the ACIP recommends that you discuss the benefits and risks of both options with the parent/caregiver.1
  • ProQuad is associated with a higher relative risk of febrile seizures at 5 to 12 days after vaccination compared with M-M-R®II and VARIVAX administered concomitantly. In a post-marketing observational safety surveillance study of children 12 to 60 months of age (N=31,298, including 31,043 who were 12 to 23 months old), the incidence of febrile seizures 5 to 12 days after ProQuad administered at Dose 1 (0.70 per 1000 children) was higher than that in children (N=31,298, including 31,019 who were 12 to 23 months old) receiving M-M-R®II and VARIVAX concomitantly (0.32 per 1000 children) [RR 2.20 (95% CI: 1.04, 4.65)].
  • A personal or family history of seizures of any etiology is a precaution for vaccination with ProQuad.1

aThe ACIP generally prefers a combination MMRV vaccine for the 1st dose at ages ≥48 months up to 12 years of age.1

CI, confidence interval; RR, relative risk.

ACIP preference for 2nd dose (routinely given at 4-6 years of age)1

  • The ACIP generally prefers a combination MMRV vaccine for the 2nd dose at any age (15 months to 12 years).1
  • In an observational post-marketing study, no cases of febrile seizure were observed during the 5- to 12-day post vaccination period among children (n=26,455) who received ProQuad as a 2nd dose.
  • A personal or family history of seizures of any etiology is a precaution for vaccination with ProQuad.1

Want to learn more about MMRV vaccines?

ProQuad® (Measles, Mumps, Rubella and Varicella Virus Vaccine Live) Logo

M-M-R®II (Measles, Mumps, and Rubella Virus Vaccine Live) Logo

VARIVAX® (Varicella Virus Vaccine Live) Logo

Reference

  1. Centers for Disease Control and Prevention (CDC). Use of combination measles, mumps, rubella, and varicella vaccine: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2010;59(RR-3):1–12.

Indications and Usage

ProQuad is a vaccine indicated for active immunization for the prevention of measles, mumps, rubella, and varicella in children 12 months through 12 years of age.

 

VARIVAX is a vaccine indicated for active immunization for the prevention of varicella in individuals 12 months of age or older.

 

M-M-R®II is indicated for active immunization for the prevention of measles, mumps, and rubella in individuals 12 months of age or older.

Selected Safety Information

  • Hypersensitivity: ProQuad, M-M-R®II, and VARIVAX are contraindicated in patients with a history of anaphylactic reaction or hypersensitivity to any component of the vaccine (including gelatin or neomycin) or to a prior dose of measles, mumps, rubella, or varicella-containing vaccine. Use caution when administering ProQuad and M-M-R®II to individuals with anaphylaxis or immediate hypersensitivity to eggs.
  • ProQuad, M-M-R®II, and VARIVAX are contraindicated in certain individuals, including those with: immunodeficiency or who are immunosuppressed; an active febrile illness; untreated tuberculosis.
  • Pregnancy: ProQuad, M-M-R®II, and VARIVAX are contraindicated for use in pregnant women. Do not administer ProQuad or VARIVAX to individuals who are planning to become pregnant in the next 3 months. Do not administer M-M-R®II to individuals who are planning to become pregnant in the next month.
  • Febrile Seizures: Administration of ProQuad (dose 1) to children 12 to 23 months old who have not been previously vaccinated against measles, mumps, rubella, or varicella, nor had a history of the wild-type infections, is associated with higher rates of fever and febrile seizures at 5 to 12 days after vaccination when compared to children vaccinated with a first dose of both M-M-R®II  and VARIVAX administered concomitantly.
  • Febrile Seizures: Use caution when administering ProQuad and M-M-R®II to individuals with a history of febrile seizures.
  • Family History of Immunodeficiency: Vaccination with ProQuad, M-M-R®II, and VARIVAX should be deferred in individuals with a family history of congenital or hereditary immunodeficiency until the individual’s immune status has been evaluated and the individual has been found to be immunocompetent.
  • Thrombocytopenia: Transient thrombocytopenia has been reported within 4-6 weeks following vaccination with measles, mumps, and rubella vaccine. Carefully evaluate the potential risk and benefit of vaccination in children with thrombocytopenia or in those who experienced thrombocytopenia after vaccination with a previous dose of a measles, mumps, and rubella-containing vaccine.
  • Varicella Transmission and Precautions: Advise vaccinees administered ProQuad or VARIVAX to avoid: close contact with high-risk individuals susceptible to varicella for up to 6 weeks following vaccination since transmission of varicella vaccine virus to susceptible contacts has been reported. Varicella vaccine virus transmission may occur between vaccine recipients and contacts susceptible to varicella including healthy individuals.
  • Immune Globulins and Transfusions: Immune Globulins and other blood products should not be given concomitantly with ProQuadM-M-R®II, or VARIVAX.
  • Use of Salicylates: Avoid use of salicylates in children and adolescents administered ProQuad or VARIVAX for 6 weeks following vaccination due to the association of Reye Syndrome with salicylate therapy and wild-type varicella infection.
  • Adverse Events: The following adverse events have been reported for both subcutaneous and intramuscular injections of ProQuad, M-M-R®II, and VARIVAX: fever, injection-site reactions (pain/tenderness/soreness, erythema, and swelling); and rash on the body or at the injection site. Additionally, irritability has been reported for the subcutaneous injections of ProQuad, M-M-R®II, and VARIVAX.
  • ProQuad Systemic Vaccine-Related Adverse Events: Systemic vaccine-related adverse events that were reported at a significantly greater rate in recipients of subcutaneous ProQuad than in recipients of the component vaccines administered concomitantly were fever and measles-like rash.
  • VARIVAX Dose-related Adverse Events: In a clinical trial involving children who received 2 doses of VARIVAX 3 months apart, the incidence of injection-site clinical complaints observed in the first 4 days following vaccination was slightly higher post-dose 2 (overall incidence 25.4%) than post-dose 1 (overall incidence 21.7%), whereas the incidence of systemic clinical complaints in the 42-day follow-up period was lower post-dose 2 (66.3%) than post-dose 1 (85.8%).
  • Concomitant Vaccines With ProQuad:ProQuad may be administered concomitantly with diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed (DTaP), Haemophilus influenzae type b conjugate (meningococcal protein conjugate) and hepatitis B (recombinant) vaccine. It may also be administered concomitantly with pneumococcal 7-valent conjugate vaccine and/or hepatitis A vaccine (inactivated) at separate injection sites.
  • Concomitant Vaccines With VARIVAX:VARIVAX can be administered with other live viral vaccines. If not given concurrently, at least 1 month should elapse between a dose of a live attenuated measles virus-containing vaccine and a dose of VARIVAX. In children, at least 3 months should elapse between administration of 2 doses of a live attenuated varicella virus-containing vaccine.
  • Tuberculin Testing: If a tuberculin test is to be done with M-M-R®II and ProQuad, it should be administered either any time before, simultaneously with, or at least 4 to 6 weeks after vaccination. With VARIVAX, tuberculin testing may be performed before the vaccine is administered or at least 4 weeks following vaccination.
  • Additional M-M-R®II Precautions: Additional adverse reactions, which have been reported without regard to causality, include febrile convulsions, arthritis, thrombocytopenia, anaphylaxis, anaphylactoid reactions, arthritis, encephalitis and encephalopathy in their diverse clinical presentations.
  • Additional VARIVAX Precautions: It is not known if varicella vaccine virus is excreted in human milk. A boost in antibody levels has been observed in vaccinees following exposure to wild-type varicella, which could account for the apparent long-term persistence of antibody levels in studies. The duration of protection from varicella infection after vaccination is unknown.
  • ProQuad/VARIVAX and Herpes Zoster: The long-term effect of VARIVAX on the incidence of herpes zoster, particularly in those vaccinees exposed to wild-type varicella, is unknown at present.
  • Efficacy: Vaccination with ProQuadVARIVAX, or M-M-R®II may not result in protection in 100% of vaccinees.

Dosage and Administration

ProQuad:

  • Each dose of ProQuad is approximately 0.5 mL and is administered intramuscularly or subcutaneously.
  • At least 1 month should elapse between a dose of a measles-containing vaccine such as M-M-R®II and a dose of ProQuad. At least 3 months should elapse between a dose of varicella-containing vaccine and ProQuad.

VARIVAX:

  • Each dose is approximately 0.5 mL and is administered intramuscularly or subcutaneously.
    • The first dose is administered at 12 to 15 months of age.
    • The second dose is administered at 4 to 6 years of age.
    • There should be a minimum interval of 3 months between doses.
    • 12 months to 12 years of age: If a second dose is administered, there should be a minimum interval of 3 months between doses.
    • Adolescents (≥13 years of age) and Adults: 2 doses, to be administered with a minimum interval of 4 weeks between doses.

M-M-R®II:

  • The dose for any age is approximately 0.5 mL administered intramuscularly or subcutaneously.
    • The recommended age for primary vaccination is 12 to 15 months and the second dose should be given at 4 to 6 years of age.

Before administering VARIVAX® (Varicella Virus Vaccine Live), M-M-R®II (Measles, Mumps, and Rubella Virus Vaccine Live), or ProQuad® (Measles, Mumps, Rubella and Varicella Virus Vaccine Live), please read the accompanying Prescribing Information. The Patient Information also is available for VARIVAX, M-M-R®II, and ProQuad.

Indications and Usage

ProQuad is a vaccine indicated for active immunization for the prevention of measles, mumps, rubella, and varicella in children 12 months through 12 years of age.

 

VARIVAX is a vaccine indicated for active immunization for the prevention of varicella in individuals 12 months of age or older.

 

M-M-R®II is indicated for active immunization for the prevention of measles, mumps, and rubella in individuals 12 months of age or older.

ProQuad is a vaccine indicated for active immunization for the prevention of measles, mumps,

ProQuad is a vaccine indicated for active immunization for the prevention of measles, mumps, rubella, and varicella in children 12 months through 12 years of age.

 

VARIVAX is a vaccine indicated for active immunization for the prevention of varicella in individuals 12 months of age or older.

Selected Safety Information

  • Hypersensitivity: ProQuad, M-M-R®II, and VARIVAX are contraindicated in patients with a history of anaphylactic reaction or hypersensitivity to any component of the vaccine (including gelatin or neomycin) or to a prior dose of measles, mumps, rubella, or varicella-containing vaccine. Use caution when administering ProQuad and M-M-R®II to individuals with anaphylaxis or immediate hypersensitivity to eggs.
  • ProQuad, M-M-R®II, and VARIVAX are contraindicated in certain individuals, including those with: immunodeficiency or who are immunosuppressed; an active febrile illness; untreated tuberculosis.
  • Pregnancy: ProQuad, M-M-R®II, and VARIVAX are contraindicated for use in pregnant women. Do not administer ProQuad or VARIVAX to individuals who are planning to become pregnant in the next 3 months. Do not administer M-M-R®II to individuals who are planning to become pregnant in the next month.
  • Febrile Seizures: Administration of ProQuad (dose 1) to children 12 to 23 months old who have not been previously vaccinated against measles, mumps, rubella, or varicella, nor had a history of the wild-type infections, is associated with higher rates of fever and febrile seizures at 5 to 12 days after vaccination when compared to children vaccinated with a first dose of both M-M-R®II  and VARIVAX administered concomitantly.
  • Febrile Seizures: Use caution when administering ProQuad and M-M-R®II to individuals with a history of febrile seizures.
  • Family History of Immunodeficiency: Vaccination with ProQuad, M-M-R®II, and VARIVAX should be deferred in individuals with a family history of congenital or hereditary immunodeficiency until the individual’s immune status has been evaluated and the individual has been found to be immunocompetent.
  • Thrombocytopenia: Transient thrombocytopenia has been reported within 4-6 weeks following vaccination with measles, mumps, and rubella vaccine. Carefully evaluate the potential risk and benefit of vaccination in children with thrombocytopenia or in those who experienced thrombocytopenia after vaccination with a previous dose of a measles, mumps, and rubella-containing vaccine.
  • Varicella Transmission and Precautions: Advise vaccinees administered ProQuad or VARIVAX to avoid: close contact with high-risk individuals susceptible to varicella for up to 6 weeks following vaccination since transmission of varicella vaccine virus to susceptible contacts has been reported. Varicella vaccine virus transmission may occur between vaccine recipients and contacts susceptible to varicella including healthy individuals.
  • Immune Globulins and Transfusions: Immune Globulins and other blood products should not be given concomitantly with ProQuadM-M-R®II, or VARIVAX.
  • Use of Salicylates: Avoid use of salicylates in children and adolescents administered ProQuad or VARIVAX for 6 weeks following vaccination due to the association of Reye Syndrome with salicylate therapy and wild-type varicella infection.
  • Adverse Events: The following adverse events have been reported for both subcutaneous and intramuscular injections of ProQuad, M-M-R®II, and VARIVAX: fever, injection-site reactions (pain/tenderness/soreness, erythema, and swelling); and rash on the body or at the injection site. Additionally, irritability has been reported for the subcutaneous injections of ProQuad, M-M-R®II, and VARIVAX.
  • ProQuad Systemic Vaccine-Related Adverse Events: Systemic vaccine-related adverse events that were reported at a significantly greater rate in recipients of subcutaneous ProQuad than in recipients of the component vaccines administered concomitantly were fever and measles-like rash.
  • VARIVAX Dose-related Adverse Events: In a clinical trial involving children who received 2 doses of VARIVAX 3 months apart, the incidence of injection-site clinical complaints observed in the first 4 days following vaccination was slightly higher post-dose 2 (overall incidence 25.4%) than post-dose 1 (overall incidence 21.7%), whereas the incidence of systemic clinical complaints in the 42-day follow-up period was lower post-dose 2 (66.3%) than post-dose 1 (85.8%).
  • Concomitant Vaccines With ProQuad:ProQuad may be administered concomitantly with diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed (DTaP), Haemophilus influenzae type b conjugate (meningococcal protein conjugate) and hepatitis B (recombinant) vaccine. It may also be administered concomitantly with pneumococcal 7-valent conjugate vaccine and/or hepatitis A vaccine (inactivated) at separate injection sites.
  • Concomitant Vaccines With VARIVAX:VARIVAX can be administered with other live viral vaccines. If not given concurrently, at least 1 month should elapse between a dose of a live attenuated measles virus-containing vaccine and a dose of VARIVAX. In children, at least 3 months should elapse between administration of 2 doses of a live attenuated varicella virus-containing vaccine.
  • Tuberculin Testing: If a tuberculin test is to be done with M-M-R®II and ProQuad, it should be administered either any time before, simultaneously with, or at least 4 to 6 weeks after vaccination. With VARIVAX, tuberculin testing may be performed before the vaccine is administered or at least 4 weeks following vaccination.
  • Additional M-M-R®II Precautions: Additional adverse reactions, which have been reported without regard to causality, include febrile convulsions, arthritis, thrombocytopenia, anaphylaxis, anaphylactoid reactions, arthritis, encephalitis and encephalopathy in their diverse clinical presentations.
  • Additional VARIVAX Precautions: It is not known if varicella vaccine virus is excreted in human milk. A boost in antibody levels has been observed in vaccinees following exposure to wild-type varicella, which could account for the apparent long-term persistence of antibody levels in studies. The duration of protection from varicella infection after vaccination is unknown.
  • ProQuad/VARIVAX and Herpes Zoster: The long-term effect of VARIVAX on the incidence of herpes zoster, particularly in those vaccinees exposed to wild-type varicella, is unknown at present.
  • Efficacy: Vaccination with ProQuadVARIVAX, or M-M-R®II may not result in protection in 100% of vaccinees.

Dosage and Administration

ProQuad:

  • Each dose of ProQuad is approximately 0.5 mL and is administered intramuscularly or subcutaneously.
  • At least 1 month should elapse between a dose of a measles-containing vaccine such as M-M-R®II and a dose of ProQuad. At least 3 months should elapse between a dose of varicella-containing vaccine and ProQuad.

VARIVAX:

  • Each dose is approximately 0.5 mL and is administered intramuscularly or subcutaneously.
    • The first dose is administered at 12 to 15 months of age.
    • The second dose is administered at 4 to 6 years of age.
    • There should be a minimum interval of 3 months between doses.
    • 12 months to 12 years of age: If a second dose is administered, there should be a minimum interval of 3 months between doses.
    • Adolescents (≥13 years of age) and Adults: 2 doses, to be administered with a minimum interval of 4 weeks between doses.

M-M-R®II:

  • The dose for any age is approximately 0.5 mL administered intramuscularly or subcutaneously.
    • The recommended age for primary vaccination is 12 to 15 months and the second dose should be given at 4 to 6 years of age.

Before administering VARIVAX® (Varicella Virus Vaccine Live), M-M-R®II (Measles, Mumps, and Rubella Virus Vaccine Live), or ProQuad® (Measles, Mumps, Rubella and Varicella Virus Vaccine Live), please read the accompanying Prescribing Information. The Patient Information also is available for VARIVAX, M-M-R®II, and ProQuad.

Hypersensitivity: ProQuadM-M-R®II, and VARIVAX are contraindicated in patients with a

Hypersensitivity: ProQuadM-M-R®II, and VARIVAX are contraindicated in patients with a history of anaphylactic reaction or hypersensitivity to any component of the vaccine (including gelatin or neomycin) or to a prior dose of measles, mumps, rubella, or varicella-containing vaccine. Use caution when administering ProQuad and M-M-R®II to individuals with anaphylaxis or